tert-butyl N-(2-fluoro-4-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)benzyl)sulfamoylcarbamate

Base Information

Chemical Name:tert-butyl N-(2-fluoro-4-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)benzyl)sulfamoylcarbamate
CAS No.:1428790-41-3
Molecular Formula:C₂₈H₃₇F₄N₅O₅S
Molecular Weight:631.692
Hs Code.:

tert-butyl N-(2-fluoro-4-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)benzyl)sulfamoylcarbamate

Synonyms:tert-butyl N-(2-fluoro-4-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)benzyl)sulfamoylcarbamate

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Chemical Property of tert-butyl N-(2-fluoro-4-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)benzyl)sulfamoylcarbamate

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Technology Process of tert-butyl N-(2-fluoro-4-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)benzyl)sulfamoylcarbamate

There total 9 articles about tert-butyl N-(2-fluoro-4-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)benzyl)sulfamoylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428790-40-2
2-(4-(aminomethyl)-3-fluorophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

: 147000-89-3
N-tert-butyloxycarbonylsulfamoyl chloride

: 1428790-41-3
tert-butyl N-(2-fluoro-4-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)benzyl)sulfamoylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 23 ℃; for 15h;

Reference yield:

: 78543-07-4
ethyl 2-(3-fluoro-4-nitrophenyl)propionate

: 1428790-41-3
tert-butyl N-(2-fluoro-4-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)benzyl)sulfamoylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 6 h

2.1: sodium nitrite; potassium iodide; p-toluenesulfonic acid monohydrate / acetonitrile / 4.17 h / 10 - 20 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; 5-(N,N-dimethyl)amiloride hydrochloride / 15 h / 120 °C / Inert atmosphere

4.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

5.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; triethylamine / 20 °C

6.1: nickel(II) chloride hexahydrate / ethanol / 0.25 h

6.2: 2 h

7.1: triethylamine / dichloromethane / 15 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; p-toluenesulfonic acid monohydrate; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; potassium iodide; sodium hydroxide; 5-(N,N-dimethyl)amiloride hydrochloride; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1402585-18-5
ethyl 2-(3-fluoro-4-iodophenyl)propanoate

: 1428790-41-3
tert-butyl N-(2-fluoro-4-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)benzyl)sulfamoylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; 5-(N,N-dimethyl)amiloride hydrochloride / 15 h / 120 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

3.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; triethylamine / 20 °C

4.1: nickel(II) chloride hexahydrate / ethanol / 0.25 h

4.2: 2 h

5.1: triethylamine / dichloromethane / 15 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel(II) chloride hexahydrate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; sodium hydroxide; 5-(N,N-dimethyl)amiloride hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; water;