diethyl 2-((2-hydroxyethyl)(2-(trityloxy)ethyl)amino)ethylphosphonate

Base Information

• Chemical Name: diethyl 2-((2-hydroxyethyl)(2-(trityloxy)ethyl)amino)ethylphosphonate
• CAS No.: 1383381-63-2
• Molecular Formula: C₂₉H₃₈NO₅P
• Molecular Weight: 511.598
• Mol file: 1383381-63-2.mol

Synonyms:diethyl 2-((2-hydroxyethyl)(2-(trityloxy)ethyl)amino)ethylphosphonate

Chemical Property of diethyl 2-((2-hydroxyethyl)(2-(trityloxy)ethyl)amino)ethylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-((2-hydroxyethyl)(2-(trityloxy)ethyl)amino)ethylphosphonate

There total 2 articles about diethyl 2-((2-hydroxyethyl)(2-(trityloxy)ethyl)amino)ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

diethyl 2-(bis(2-hydroxyethyl)amino)ethylphosphonate (13269-89-1) + trityl chloride (76-83-5) → diethyl 2-((2-hydroxyethyl)(2-(trityloxy)ethyl)amino)ethylphosphonate (1383381-63-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm300662d

Reference yield:

Diethyl vinylphosphonate (682-30-4) → diethyl 2-((2-hydroxyethyl)(2-(trityloxy)ethyl)amino)ethylphosphonate (1383381-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: water / 20 °C

2: dmap; triethylamine / dichloromethane / 20 °C

With dmap; triethylamine; In dichloromethane; water;

DOI:10.1021/jm300662d

Reference yield: 76.0%

diethyl 2-((2-hydroxyethyl)(2-(trityloxy)ethyl)amino)ethylphosphonate (1383381-63-2) + 2-chloro-7H-purine (1681-15-8) → diethyl 9-[(N-(2-(trityloxy)ethyl)-N-(2-phosphonoethyl))-2-aminoethyl]-6-chloropurine (1383381-71-2)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at -30 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jm300662d

upstream raw materials:

diethyl 2-(bis(2-hydroxyethyl)amino)ethylphosphonate

trityl chloride

Diethyl vinylphosphonate

Downstream raw materials:

diethyl 9-[(N-(2-(trityloxy)ethyl)-N-(2-phosphonoethyl))-2-aminoethyl]-6-chloropurine

C₅₂H₅₃ClN₆O₄P₂