N-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propyl)-N-phenyl-oxalamic acid methyl ester

Base Information

• Chemical Name: N-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propyl)-N-phenyl-oxalamic acid methyl ester
• CAS No.: 206753-68-6
• Molecular Formula: C₂₃H₂₈N₂O₅
• Molecular Weight: 412.486
• Mol file: 206753-68-6.mol

Synonyms:N-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propyl)-N-phenyl-oxalamic acid methyl ester

Chemical Property of N-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propyl)-N-phenyl-oxalamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propyl)-N-phenyl-oxalamic acid methyl ester

There total 3 articles about N-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propyl)-N-phenyl-oxalamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

monomethyl oxalyl chloride (5781-53-3) + ((S)-2-Phenyl-1-phenylaminomethyl-ethyl)-carbamic acid tert-butyl ester (206753-67-5) → N-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propyl)-N-phenyl-oxalamic acid methyl ester (206753-68-6)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; at 0 ℃; for 0.5h;

DOI:10.1021/jo9800309

Reference yield:

Boc-L-phenylalaninal (72155-45-4) → N-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propyl)-N-phenyl-oxalamic acid methyl ester (206753-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / 4A MS, Na(OAc)3BH / 1,2-dichloro-ethane / 2 h

2: 99 percent / NaHCO₃ / ethyl acetate / 0.5 h / 0 °C

With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; In ethyl acetate; 1,2-dichloro-ethane;

DOI:10.1021/jo9800309

Reference yield:

aniline (62-53-3) → N-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propyl)-N-phenyl-oxalamic acid methyl ester (206753-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / 4A MS, Na(OAc)3BH / 1,2-dichloro-ethane / 2 h

2: 99 percent / NaHCO₃ / ethyl acetate / 0.5 h / 0 °C

With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; In ethyl acetate; 1,2-dichloro-ethane;

DOI:10.1021/jo9800309

upstream raw materials:

monomethyl oxalyl chloride

((S)-2-Phenyl-1-phenylaminomethyl-ethyl)-carbamic acid tert-butyl ester

Boc-L-phenylalaninal

aniline

Downstream raw materials:

N-((S)-2-Amino-3-phenyl-propyl)-N-phenyl-oxalamic acid methyl ester