206753-67-5Relevant academic research and scientific papers
(4-Piperidinylphenyl)aminoethyl amides as a novel class of non-covalent cathepsin K inhibitors
Kim, Tae-Seong,Hague, Andrew B.,Lee, Tony I.,Lian, Brian,Tegley, Christopher M.,Wang, Xianghong,Burgess, Teresa L.,Qian, Yi-Xin,Ross, Sandra,Tagari, Philip,Lin, Chi-Hwei,Mayeda, Carol,Dao, Jennifer,Jordan, Steven,Mohr, Christopher,Cheetham, Janet,Viswanadhan, Vellarkad,Tasker, Andrew S.
, p. 87 - 90 (2007/10/03)
A series of (4-piperidinylphenyl)aminoethyl amides based on dipeptide anilines were synthesized and tested against cathepsin K, cathepsin L and cathepsin B. These new non-covalent inhibitors exhibited single-digit nM inhibition of the cysteine proteases. Compounds 3 and 7 demonstrated potency in both mouse and human osteoclast resorption assays.
