N-{2-chloro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Base Information

Chemical Name:N-{2-chloro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide
CAS No.:1307296-89-4
Molecular Formula:C₂₃H₂₈ClN₅O₄S₂
Molecular Weight:538.091
Hs Code.:

Synonyms:N-{2-chloro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

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Chemical Property of N-{2-chloro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

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Technology Process of N-{2-chloro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

There total 8 articles about N-{2-chloro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.3%

: 1307272-41-8
N-{2-chloro-3-[5-(2-chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

: 141-43-5
ethanolamine

: 1307296-89-4
N-{2-chloro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Guidance literature:: In 1,4-dioxane; at 140 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 344329-76-6
tetrahydro-pyran-4-carboxylic acid amide

: 1307296-89-4
N-{2-chloro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Lawessons reagent / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

2.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 1.5 h / 20 - 60 °C / Inert atmosphere

3.1: 1,4-dioxane / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

With Lawessons reagent; N-Bromosuccinimide; In tetrahydrofuran; 1,4-dioxane; ISOPROPYLAMIDE;

Reference yield:

: 1307272-36-1
N-(2-chloro-3-(2-(2-chloropyrimidin-4-yl)acetyl)phenyl)propane-1-sulfonamide

: 1307296-89-4
N-{2-chloro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 1.5 h / 20 - 60 °C / Inert atmosphere

2.1: 1,4-dioxane / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

With N-Bromosuccinimide; In 1,4-dioxane; ISOPROPYLAMIDE;