2-{2-[(benzyloxy-formyl-amino)-methyl]-3-phenyl-propionylamino}-3,3,N,N-tetramethyl-butyramide

Base Information

Chemical Name:2-{2-[(benzyloxy-formyl-amino)-methyl]-3-phenyl-propionylamino}-3,3,N,N-tetramethyl-butyramide
CAS No.:607715-39-9
Molecular Formula:C₂₆H₃₅N₃O₄
Molecular Weight:453.582
Hs Code.:

2-{2-[(benzyloxy-formyl-amino)-methyl]-3-phenyl-propionylamino}-3,3,<i>N</i>,<i>N</i>-tetramethyl-butyramide

Synonyms:2-{2-[(benzyloxy-formyl-amino)-methyl]-3-phenyl-propionylamino}-3,3,N,N-tetramethyl-butyramide

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Chemical Property of 2-{2-[(benzyloxy-formyl-amino)-methyl]-3-phenyl-propionylamino}-3,3,N,N-tetramethyl-butyramide

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Technology Process of 2-{2-[(benzyloxy-formyl-amino)-methyl]-3-phenyl-propionylamino}-3,3,N,N-tetramethyl-butyramide

There total 6 articles about 2-{2-[(benzyloxy-formyl-amino)-methyl]-3-phenyl-propionylamino}-3,3,N,N-tetramethyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 72773-04-7
N-formylbenzotriazole

: 607715-18-4
2-[2-(benzyloxyamino-methyl)-3-phenyl-propionylamino]-3,3,N,N-tetramethyl-butyramide

: 607715-39-9
2-{2-[(benzyloxy-formyl-amino)-methyl]-3-phenyl-propionylamino}-3,3,N,N-tetramethyl-butyramide

Guidance literature:: In tetrahydrofuran;
DOI:10.1016/S0960-894X(03)00532-8

Reference yield:

: 2021-28-5
ethyl dihydrocinnamate

: 607715-39-9
2-{2-[(benzyloxy-formyl-amino)-methyl]-3-phenyl-propionylamino}-3,3,N,N-tetramethyl-butyramide

Guidance literature:: Multi-step reaction with 6 steps

1: EtONa

2: NaOAc / aq. ethanol

3: 100 percent / NaOH / methanol

4: EDC; HOAt / dimethylformamide

5: NaCNBH₃; AcOH

6: 86 percent / tetrahydrofuran

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; sodium ethanolate; sodium acetate; sodium cyanoborohydride; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00532-8

Reference yield:

: 98516-80-4,2016-00-4
ethyl 2-formyl-3-phenylpropionate

: 607715-39-9
2-{2-[(benzyloxy-formyl-amino)-methyl]-3-phenyl-propionylamino}-3,3,N,N-tetramethyl-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: NaOAc / aq. ethanol

2: 100 percent / NaOH / methanol

3: EDC; HOAt / dimethylformamide

4: NaCNBH₃; AcOH

5: 86 percent / tetrahydrofuran

With sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; sodium acetate; sodium cyanoborohydride; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00532-8