methyl 4-(3-(4-(azepan-1-yl)-2-chlorobenzyl)ureido)-1H-indazole-1-carboxylate

Base Information

Chemical Name:methyl 4-(3-(4-(azepan-1-yl)-2-chlorobenzyl)ureido)-1H-indazole-1-carboxylate
CAS No.:946388-39-2
Molecular Formula:C₂₃H₂₆ClN₅O₃
Molecular Weight:455.944
Hs Code.:

Synonyms:methyl 4-(3-(4-(azepan-1-yl)-2-chlorobenzyl)ureido)-1H-indazole-1-carboxylate

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Chemical Property of methyl 4-(3-(4-(azepan-1-yl)-2-chlorobenzyl)ureido)-1H-indazole-1-carboxylate

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Technology Process of methyl 4-(3-(4-(azepan-1-yl)-2-chlorobenzyl)ureido)-1H-indazole-1-carboxylate

There total 5 articles about methyl 4-(3-(4-(azepan-1-yl)-2-chlorobenzyl)ureido)-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 902131-30-0
4-isocyanatoindazol-1-carboxylic acid methyl ester

: 735330-87-7
(4-(azepan-1-yl)-2-chlorophenyl)methanamine

: 946388-39-2
methyl 4-(3-(4-(azepan-1-yl)-2-chlorobenzyl)ureido)-1H-indazole-1-carboxylate

Guidance literature:: In tetrahydrofuran; diethyl ether; at 20 ℃; for 18h;
DOI:10.1021/jm070276i

Reference yield:

: 111-49-9
hexamethylene imine

: 946388-39-2
methyl 4-(3-(4-(azepan-1-yl)-2-chlorobenzyl)ureido)-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylsulfoxide / 120 °C

2: LiAlH₄ / tetrahydrofuran / Heating

3: 76 percent / tetrahydrofuran; diethyl ether / 18 h / 20 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1021/jm070276i

Reference yield:

: 20925-52-4
C₁₃H₁₅ClN₂

: 946388-39-2
methyl 4-(3-(4-(azepan-1-yl)-2-chlorobenzyl)ureido)-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / Heating

2: 76 percent / tetrahydrofuran; diethyl ether / 18 h / 20 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm070276i