N-[(E)-5-((2R,3S)-2-(4-hydroxybenzyl)-3-hydroxy-5-oxopyrrolidin-1-yl)-3-methoxy-5-oxopent-3-enyl]-6,6-dimethylheptanamide

Base Information

• Chemical Name: N-[(E)-5-((2R,3S)-2-(4-hydroxybenzyl)-3-hydroxy-5-oxopyrrolidin-1-yl)-3-methoxy-5-oxopent-3-enyl]-6,6-dimethylheptanamide
• CAS No.: 1190757-98-2
• Molecular Formula: C₂₆H₃₈N₂O₆
• Molecular Weight: 474.598

Synonyms:N-[(E)-5-((2R,3S)-2-(4-hydroxybenzyl)-3-hydroxy-5-oxopyrrolidin-1-yl)-3-methoxy-5-oxopent-3-enyl]-6,6-dimethylheptanamide

Chemical Property of N-[(E)-5-((2R,3S)-2-(4-hydroxybenzyl)-3-hydroxy-5-oxopyrrolidin-1-yl)-3-methoxy-5-oxopent-3-enyl]-6,6-dimethylheptanamide

Chemical Property:

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Technology Process of N-[(E)-5-((2R,3S)-2-(4-hydroxybenzyl)-3-hydroxy-5-oxopyrrolidin-1-yl)-3-methoxy-5-oxopent-3-enyl]-6,6-dimethylheptanamide

There total 1 articles about N-[(E)-5-((2R,3S)-2-(4-hydroxybenzyl)-3-hydroxy-5-oxopyrrolidin-1-yl)-3-methoxy-5-oxopent-3-enyl]-6,6-dimethylheptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-[(E)-5-((2R,3S)-2-(4-(benzyloxy)benzyl)-3-(benzyloxy)-5-oxopyrrolidin-1-yl)-3-methoxy-5-oxopent-3-enyl]-6,6-dimethylheptanamide (1190758-12-3) → N-[(E)-5-((2R,3S)-2-(4-hydroxybenzyl)-3-hydroxy-5-oxopyrrolidin-1-yl)-3-methoxy-5-oxopent-3-enyl]-6,6-dimethylheptanamide (1190757-98-2)

Guidance literature:

With formic acid; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jo901557h

Reference yield: 94.0%

N-[(E)-5-((2R,3S)-2-(4-hydroxybenzyl)-3-hydroxy-5-oxopyrrolidin-1-yl)-3-methoxy-5-oxopent-3-enyl]-6,6-dimethylheptanamide (1190757-98-2) + acetic anhydride (108-24-7) → 4-[((2R,3S)-3-acetoxy-1-((E)-5-(6,6-dimethylheptanamido)-3-methoxypent-2-enoyl)-5-oxopyrrolidin-2-yl)methyl]phenyl acetate (1190758-16-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 8h;

DOI:10.1021/jo901557h

Reference yield: 92.0%

N-[(E)-5-((2R,3S)-2-(4-hydroxybenzyl)-3-hydroxy-5-oxopyrrolidin-1-yl)-3-methoxy-5-oxopent-3-enyl]-6,6-dimethylheptanamide (1190757-98-2) + acetic anhydride (108-24-7) → 4-[((2R,3S)-1-((E)-5-(6,6-dimethylheptanamido)-3-methoxypent-2-enoyl)-3-hydroxy-5-oxopyrrolidin-2-yl)methyl]phenyl acetate (1190758-15-6)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/jo901557h

upstream raw materials:

N-[(E)-5-((2R,3S)-2-(4-(benzyloxy)benzyl)-3-(benzyloxy)-5-oxopyrrolidin-1-yl)-3-methoxy-5-oxopent-3-enyl]-6,6-dimethylheptanamide

Downstream raw materials:

C₃₁H₄₄N₂O₇

4-[((2R,3S)-1-((E)-5-(6,6-dimethylheptanamido)-3-methoxypent-2-enoyl)-3-hydroxy-5-oxopyrrolidin-2-yl)methyl]phenyl acetate

4-[((2R,3S)-3-acetoxy-1-((E)-5-(6,6-dimethylheptanamido)-3-methoxypent-2-enoyl)-5-oxopyrrolidin-2-yl)methyl]phenyl acetate

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