prop-2-en-1-yl 2-[(4'-chlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(5-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoate

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Chemical Name:prop-2-en-1-yl 2-[(4'-chlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(5-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoate
CAS No.:1369963-15-4
Molecular Formula:C₂₉H₂₇ClN₂O₆S
Molecular Weight:567.062
Hs Code.:

Synonyms:prop-2-en-1-yl 2-[(4'-chlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(5-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoate

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Chemical Property of prop-2-en-1-yl 2-[(4'-chlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(5-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoate

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Technology Process of prop-2-en-1-yl 2-[(4'-chlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(5-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoate

There total 6 articles about prop-2-en-1-yl 2-[(4'-chlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(5-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40314-06-5
5-methyl-1H-isoindole-1,3-(2H)-dione

: 1369962-96-8
prop-2-en-1-yl N-(4'-chlorobiphenyl-4-yl)-N-(methylsulfonyl)homoserinate

: 1369963-15-4
prop-2-en-1-yl 2-[(4'-chlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(5-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1369963-15-4
prop-2-en-1-yl 2-[(4'-chlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(5-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 1 h

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 14 h / 100 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C

4.1: sodium hydroxide; water / ethanol / 2 h / 0 °C

5.1: sodium hydrogencarbonate / N,N-dimethyl-formamide; ethanol; water / 0.5 h / 20 °C

5.2: 20 °C

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C

With pyridine; di-isopropyl azodicarboxylate; water; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 4284-50-8
N-(4-bromophenyl)methanesulfonamide

: 1369963-15-4
prop-2-en-1-yl 2-[(4'-chlorobiphenyl-4-yl)(methylsulfonyl)amino]-4-(5-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 14 h / 100 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: sodium hydroxide; water / ethanol / 2 h / 0 °C

4.1: sodium hydrogencarbonate / N,N-dimethyl-formamide; ethanol; water / 0.5 h / 20 °C

4.2: 20 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; water; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;