2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)-propionic acid

Base Information

• Chemical Name: 2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)-propionic acid
• CAS No.: 59686-55-4
• Molecular Formula: C₁₄H₁₉NO₆
• Molecular Weight: 297.308
• Mol file: 59686-55-4.mol

Synonyms:2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)-propionic acid

Chemical Property of 2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)-propionic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)-propionic acid

There total 3 articles about 2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.5%

dopa (63-84-3,90638-38-3) + di-tert-butyl dicarbonate (24424-99-5) → 2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)-propionic acid (59686-55-4)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2010.01.041

Reference yield: 86.2%

di-tert-butyl dicarbonate (24424-99-5) + levodopa (59-92-7,90638-38-3) → 2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)-propionic acid (59686-55-4)

Guidance literature:

With sodium hydroxide; at 0 - 20 ℃; for 6h;

DOI:10.1039/c4cc02775b

Reference yield:

→ 2-(tert-butoxycarbonylamino)-3-(3,4-dihydroxyphenyl)-propionic acid (59686-55-4)

Guidance literature:

5, CH3OH/NaOH/N2H4;

DOI:10.1021/jo00880a040

upstream raw materials:

dopa

di-tert-butyl dicarbonate

levodopa

Downstream raw materials:

N-tert-butoxycarbonyl-3,4-bisdifluoromethoxy-D,L-phenylalanine

3,4-bisdifluoromethoxy-D,L-phenylalanine

C₁₄H₁₇NO₆

[2-tert-butoxycarbonylamino-3-(3,4-dihydroxyphenyl)-propionylamino]-acetic acid methyl ester