Technology Process of (2E/Z)-2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-[(4-methoxy-3-{5-[(4-methyl-1-piperazinyl)methyl]-3-furanyl}phenyl)amino]-2-propenamide
There total 10 articles about (2E/Z)-2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-[(4-methoxy-3-{5-[(4-methyl-1-piperazinyl)methyl]-3-furanyl}phenyl)amino]-2-propenamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 3 steps
1.1: 18 percent / sodium triacetoxyborohydride; acetic acid / 1-methyl-pyrrolidin-2-one; CH2Cl2 / 0 - 20 °C
2.1: 100 percent / hydrogen / Pd/C / methanol
3.1: propan-2-ol / Heating
3.2: propan-2-ol / 25 h / Heating
With
hydrogen; sodium tris(acetoxy)borohydride; acetic acid;
palladium on activated charcoal;
In
1-methyl-pyrrolidin-2-one; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm061031t
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: aq. NaHCO3 / tetrakis(triphenylphosphine)palladium(0) / 1,2-dimethoxy-ethane / Heating
2.1: 18 percent / sodium triacetoxyborohydride; acetic acid / 1-methyl-pyrrolidin-2-one; CH2Cl2 / 0 - 20 °C
3.1: 100 percent / hydrogen / Pd/C / methanol
4.1: propan-2-ol / Heating
4.2: propan-2-ol / 25 h / Heating
With
hydrogen; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; acetic acid;
palladium on activated charcoal; tetrakis(triphenylphosphine) palladium(0);
In
1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm061031t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium; tri-iso-propyl borate / tetrahydrofuran; hexane / -78 - 20 °C
1.2: H2O / tetrahydrofuran; hexane
2.1: 900 mg / aq. Na2CO3 / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1,2-dimethoxy-ethane / 3 h / Heating
3.1: propan-2-ol / Heating
3.2: propan-2-ol / 25 h / Heating
With
n-butyllithium; Triisopropyl borate; sodium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; 1,2-dimethoxyethane; hexane; isopropyl alcohol;
2.1: Suzuki coupling;
DOI:10.1021/jm061031t