2-(2-((2-Chloro-6-methylphenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamido)-5-(trifluoromethyl)pyridine 1-oxide

Base Information

Chemical Name:2-(2-((2-Chloro-6-methylphenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamido)-5-(trifluoromethyl)pyridine 1-oxide
CAS No.:1374297-58-1
Molecular Formula:C₂₅H₂₁ClF₃N₅O₃
Molecular Weight:531.922
Hs Code.:

Synonyms:2-(2-((2-Chloro-6-methylphenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamido)-5-(trifluoromethyl)pyridine 1-oxide

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Chemical Property of 2-(2-((2-Chloro-6-methylphenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamido)-5-(trifluoromethyl)pyridine 1-oxide

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Technology Process of 2-(2-((2-Chloro-6-methylphenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamido)-5-(trifluoromethyl)pyridine 1-oxide

There total 8 articles about 2-(2-((2-Chloro-6-methylphenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamido)-5-(trifluoromethyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374298-64-2
2-((2-chloro-6-methylphenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro-[4,5-d]imidazole-5-carboxylic acid

: 5-(trifluoromethyl) pyridin-2-amine N-oxide

: 1374297-58-1
2-(2-((2-Chloro-6-methylphenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamido)-5-(trifluoromethyl)pyridine 1-oxide

Guidance literature:: 2-((2-chloro-6-methylphenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro-[4,5-d]imidazole-5-carboxylic acid; With C₁₄H₂₂N₃O₃⁽¹⁺⁾*F₆P^(1-); N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

5-(trifluoromethyl) pyridin-2-amine N-oxide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2018.02.048

Reference yield:

: 106125-55-7
methyl 4-amino-2-hydroxy-5-nitrobenzoate

: 1374297-58-1
2-(2-((2-Chloro-6-methylphenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamido)-5-(trifluoromethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

2.1: N,N-dimethyl-aniline / 1.5 h / Reflux

2.2: 100 °C

3.1: iron / methanol / 0 °C

3.2: 2 h / 20 °C

4.1: acetonitrile / 24 h / 20 °C

4.2: 20 °C

5.1: sodium hydroxide / water / 20 - 60 °C

6.1: C₁₄H₂₂N₃O₃⁽¹⁺⁾*F₆P^(1-); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

6.2: 20 °C

With C₁₄H₂₂N₃O₃⁽¹⁺⁾*F₆P^(1-); iron; potassium carbonate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2018.02.048

Reference yield:

: 1374298-19-7
methyl 4, 5-diamino-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate

: 1374297-58-1
2-(2-((2-Chloro-6-methylphenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamido)-5-(trifluoromethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / 24 h / 20 °C

1.2: 20 °C

2.1: sodium hydroxide / water / 20 - 60 °C

3.1: C₁₄H₂₂N₃O₃⁽¹⁺⁾*F₆P^(1-); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 20 °C

With C₁₄H₂₂N₃O₃⁽¹⁺⁾*F₆P^(1-); N-ethyl-N,N-diisopropylamine; sodium hydroxide; In water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2018.02.048