methyl 4, 5-diamino-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate

Base Information

Chemical Name:methyl 4, 5-diamino-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate
CAS No.:1374298-19-7
Molecular Formula:C₁₂H₁₆N₂O₃
Molecular Weight:236.271
Hs Code.:

Synonyms:methyl 4, 5-diamino-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate

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Chemical Property of methyl 4, 5-diamino-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate

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Technology Process of methyl 4, 5-diamino-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate

There total 12 articles about methyl 4, 5-diamino-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1374298-18-6
methyl 4-amino-2,2-dimethyl-5-nitro-2,3-dihydrobenzofuran-7-carboxylate

: 1374298-19-7
methyl 4, 5-diamino-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate

Guidance literature:: With hydrogenchloride; iron; In methanol; water; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2017.10.062

Reference yield:

: 1583-58-0
2,4-difluoro-benzoic acid

: 1374298-19-7
methyl 4, 5-diamino-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid; nitric acid / water / 14 h / 0 - 5 °C

2.1: sulfuric acid / ethanol / 24 h / Reflux

3.1: triethylamine / tetrahydrofuran / 0 - 26 °C

4.1: sodium methylate / methanol; water / 0 - 26 °C

5.1: aluminum (III) chloride / 1,2-dichloro-ethane / Reflux

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C

6.2: 80 °C

7.1: N,N-diethylaniline / 1.3 h / Reflux

8.1: formic acid / 100 °C

9.1: hydrogenchloride; iron / methanol; water / 1 h / 22 - 26 °C

With hydrogenchloride; aluminum (III) chloride; formic acid; sulfuric acid; nitric acid; sodium methylate; iron; potassium carbonate; triethylamine; N,N-diethylaniline; sulfuric acid; In tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 153775-33-8
2,4-difluoro-5-nitro-benzoic acid

: 1374298-19-7
methyl 4, 5-diamino-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / ethanol / 24 h / Reflux

2.1: triethylamine / tetrahydrofuran / 0 - 26 °C

3.1: sodium methylate / methanol; water / 0 - 26 °C

4.1: aluminum (III) chloride / 1,2-dichloro-ethane / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C

5.2: 80 °C

6.1: N,N-diethylaniline / 1.3 h / Reflux

7.1: formic acid / 100 °C

8.1: hydrogenchloride; iron / methanol; water / 1 h / 22 - 26 °C

With hydrogenchloride; aluminum (III) chloride; formic acid; sodium methylate; iron; potassium carbonate; triethylamine; N,N-diethylaniline; sulfuric acid; In tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;