N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(hydroxymethyl)-1H-indazol-3-yl]-5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-2-thiophenesulfonamide

Base Information

Chemical Name:N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(hydroxymethyl)-1H-indazol-3-yl]-5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-2-thiophenesulfonamide
CAS No.:1240518-63-1
Molecular Formula:C₂₄H₂₀Cl₂N₄O₅S₄
Molecular Weight:643.617
Hs Code.:

Synonyms:N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(hydroxymethyl)-1H-indazol-3-yl]-5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-2-thiophenesulfonamide

Suppliers and Price of N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(hydroxymethyl)-1H-indazol-3-yl]-5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-2-thiophenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(hydroxymethyl)-1H-indazol-3-yl]-5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-2-thiophenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(hydroxymethyl)-1H-indazol-3-yl]-5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-2-thiophenesulfonamide

There total 10 articles about N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(hydroxymethyl)-1H-indazol-3-yl]-5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1240518-62-0
1,1-dimethylethyl [(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(hydroxymethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate

: 1240518-63-1
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(hydroxymethyl)-1H-indazol-3-yl]-5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-2-thiophenesulfonamide

Guidance literature:: 1,1-dimethylethyl [(3-{[3-{bis[(5-chloro-2-thienyl)sulfonyl]amino}-4-(hydroxymethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]carbamate; With trifluoroacetic acid; In dichloromethane; for 1h; Inert atmosphere;

With ammonia; In methanol;

Reference yield:

: 65610-13-1
3-fluoro-1,2-benzenedicarbonitrile

: 1240518-63-1
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(hydroxymethyl)-1H-indazol-3-yl]-5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1: hydrazine hydrate / ethanol / 70 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane; acetonitrile / 0.5 h / Inert atmosphere

3: dichloromethane / 62 h / 45 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 1.17 h

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 60 °C

6: diisobutylaluminium hydride / toluene / 3.75 h / -10 - 0 °C

7: sodium tetrahydroborate / methanol / 3 h / Inert atmosphere

8: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

With dmap; sodium tetrahydroborate; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; hydrazine hydrate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; acetonitrile; 5: |Mitsunobu Displacement;
DOI:10.1021/jm301572h

Reference yield:

: 874-97-5
3-(hydroxymethyl)benzonitrile

: 1240518-63-1
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(hydroxymethyl)-1H-indazol-3-yl]-5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-2-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 3 h / 0 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1 h / 60 °C

3: diisobutylaluminium hydride / toluene / 3.75 h / -10 - 0 °C

4: sodium tetrahydroborate / methanol / 3 h / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; triphenylphosphine; trifluoroacetic acid; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; toluene; 2: |Mitsunobu Displacement;
DOI:10.1021/jm301572h