2H-Benzimidazol-2-one,1-ethyl-1,3-dihydro-6-methoxy-(9CI)

Base Information

• Chemical Name: 2H-Benzimidazol-2-one,1-ethyl-1,3-dihydro-6-methoxy-(9CI)
• CAS No.: 89930-91-6
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.217
• Mol file: 89930-91-6.mol

Synonyms:1,3-Dihydro-1-ethyl-6-methoxy-2H-benzimidazol-2-one

Chemical Property of 2H-Benzimidazol-2-one,1-ethyl-1,3-dihydro-6-methoxy-(9CI)

Chemical Property:

• PKA: 11.57±0.30(Predicted)
• PSA: 0.00000
• Density: 1.174±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-Benzimidazol-2-one,1-ethyl-1,3-dihydro-6-methoxy-(9CI)

There total 4 articles about 2H-Benzimidazol-2-one,1-ethyl-1,3-dihydro-6-methoxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-ethyl-3-((4-methoxybenzoyl)oxy)-1-(3-methoxyphenyl)urea → 1-ethyl-6-methoxy-1H-benzo[d]imidazol-2(3H)-one (89930-91-6)

Guidance literature:

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 16h; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.0c02200

Reference yield:

N-methyl-N-(3-methoxyphenyl)carbamoyl chloride → 1-ethyl-6-methoxy-1H-benzo[d]imidazol-2(3H)-one (89930-91-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; triethylamine / dichloromethane / 0 - 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

3: tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; triethylamine / acetonitrile / 16 h / 20 °C / Inert atmosphere; Irradiation

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; hydroxylamine hydrochloride; triethylamine; In dichloromethane; acetonitrile;

DOI:10.1021/acs.orglett.0c02200

Reference yield:

N-ethyl-m-anisidine (41115-30-4) → 1-ethyl-6-methoxy-1H-benzo[d]imidazol-2(3H)-one (89930-91-6)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide / toluene; water / 1.5 h / 0 °C / Inert atmosphere

2: hydroxylamine hydrochloride; triethylamine / dichloromethane / 0 - 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C

4: tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; triethylamine / acetonitrile / 16 h / 20 °C / Inert atmosphere; Irradiation

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; hydroxylamine hydrochloride; triethylamine; potassium hydroxide; In dichloromethane; water; toluene; acetonitrile;

DOI:10.1021/acs.orglett.0c02200

upstream raw materials:

N-ethyl-m-anisidine