2-[2-(4-fluorophenyl)-5-(N-trifluoroacetyl-N-methylamino)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3,-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Base Information

Chemical Name:2-[2-(4-fluorophenyl)-5-(N-trifluoroacetyl-N-methylamino)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3,-trifluoro-1-isopropyl-2-oxopropyl)acetamide
CAS No.:148748-54-3
Molecular Formula:C₂₁H₁₉F₇N₄O₄
Molecular Weight:524.395
Hs Code.:

Synonyms:2-[2-(4-fluorophenyl)-5-(N-trifluoroacetyl-N-methylamino)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3,-trifluoro-1-isopropyl-2-oxopropyl)acetamide

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Chemical Property of 2-[2-(4-fluorophenyl)-5-(N-trifluoroacetyl-N-methylamino)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3,-trifluoro-1-isopropyl-2-oxopropyl)acetamide

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Technology Process of 2-[2-(4-fluorophenyl)-5-(N-trifluoroacetyl-N-methylamino)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3,-trifluoro-1-isopropyl-2-oxopropyl)acetamide

There total 11 articles about 2-[2-(4-fluorophenyl)-5-(N-trifluoroacetyl-N-methylamino)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3,-trifluoro-1-isopropyl-2-oxopropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 148748-54-3
2-[2-(4-fluorophenyl)-5-(N-trifluoroacetyl-N-methylamino)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3,-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Guidance literature:: Multi-step reaction with 11 steps

1: 103.1 g / HCl / ethanol / 16 h / Ambient temperature

2: 53 percent / methanol / 72 h / 5 °C

3: 73 percent / methanol / 1.5 h / 100 °C

4: 89 percent / pyridine, lithium iodide / 2 h / Heating

5: 1.) Et₃N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h

6: 1N aq. HCl / tetrahydrofuran / 8 h / Heating

7: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / 1 h / Ambient temperature

8: 1-hydroxybenzotriazole hydrate, Et₃N, EDC / dimethylformamide / 16 h

9: anisole, trifluoromethanesulfonic acid / CH₂Cl₂ / 0.25 h / 0 - 20 °C

10: 631 mg / CH₂Cl₂ / 4 h / Ambient temperature

11: sodium carbonate / dimethylformamide / 16 h / Ambient temperature

With pyridine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; trifluorormethanesulfonic acid; diphenyl phosphoryl azide; sodium carbonate; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; triethylamine; lithium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00001a015

Reference yield:

: 149742-99-4
methyl 1-(2,2-dimethoxyethyl)-2-(4-fluorophenyl)pyrimidin-6(1H)-one-5-carboxylate

: 148748-54-3
2-[2-(4-fluorophenyl)-5-(N-trifluoroacetyl-N-methylamino)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3,-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 89 percent / pyridine, lithium iodide / 2 h / Heating

2: 1.) Et₃N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h

3: 1N aq. HCl / tetrahydrofuran / 8 h / Heating

4: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / 1 h / Ambient temperature

5: 1-hydroxybenzotriazole hydrate, Et₃N, EDC / dimethylformamide / 16 h

6: anisole, trifluoromethanesulfonic acid / CH₂Cl₂ / 0.25 h / 0 - 20 °C

7: 631 mg / CH₂Cl₂ / 4 h / Ambient temperature

8: sodium carbonate / dimethylformamide / 16 h / Ambient temperature

With pyridine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; trifluorormethanesulfonic acid; diphenyl phosphoryl azide; sodium carbonate; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; triethylamine; lithium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00001a015

Reference yield:

: 149742-96-1
N-(2,2-dimethoxyethyl)-4-(fluorophenyl)carboxamidine

: 148748-54-3
2-[2-(4-fluorophenyl)-5-(N-trifluoroacetyl-N-methylamino)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3,-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: 73 percent / methanol / 1.5 h / 100 °C

2: 89 percent / pyridine, lithium iodide / 2 h / Heating

3: 1.) Et₃N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h

4: 1N aq. HCl / tetrahydrofuran / 8 h / Heating

5: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s) / 1 h / Ambient temperature

6: 1-hydroxybenzotriazole hydrate, Et₃N, EDC / dimethylformamide / 16 h

7: anisole, trifluoromethanesulfonic acid / CH₂Cl₂ / 0.25 h / 0 - 20 °C

8: 631 mg / CH₂Cl₂ / 4 h / Ambient temperature

9: sodium carbonate / dimethylformamide / 16 h / Ambient temperature

With pyridine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; trifluorormethanesulfonic acid; diphenyl phosphoryl azide; sodium carbonate; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; triethylamine; lithium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00001a015