(2,3-dichlorophenyl)(5-methyl-6-(2-morpholinoethyl)-6H-thieno[2,3-b]pyrrol-4-yl)methanone

Base Information

• Chemical Name: (2,3-dichlorophenyl)(5-methyl-6-(2-morpholinoethyl)-6H-thieno[2,3-b]pyrrol-4-yl)methanone
• CAS No.: 1327366-70-0
• Molecular Formula: C₂₀H₂₀Cl₂N₂O₂S
• Molecular Weight: 423.363
• Mol file: 1327366-70-0.mol

Synonyms:(2,3-dichlorophenyl)(5-methyl-6-(2-morpholinoethyl)-6H-thieno[2,3-b]pyrrol-4-yl)methanone

Chemical Property of (2,3-dichlorophenyl)(5-methyl-6-(2-morpholinoethyl)-6H-thieno[2,3-b]pyrrol-4-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,3-dichlorophenyl)(5-methyl-6-(2-morpholinoethyl)-6H-thieno[2,3-b]pyrrol-4-yl)methanone

There total 4 articles about (2,3-dichlorophenyl)(5-methyl-6-(2-morpholinoethyl)-6H-thieno[2,3-b]pyrrol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(2,3-dichlorophenyl)(5-methyl-6H-thieno[2,3-b]pyrrol-4-yI)methanone (1327366-71-1) + 4-(2-chloroethyl)morpholine hydrochride (3647-69-6) → (2,3-dichlorophenyl)(5-methyl-6-(2-morpholinoethyl)-6H-thieno[2,3-b]pyrrol-4-yl)methanone (1327366-70-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 17h; Sealed tube;

Reference yield: 14.4%

4-(2-(5-methyl-6H-thieno[2,3-b]pyrrol-6-yl)ethyl)morpholine (1261151-48-7) + 2,3-dichlorobenzoyl chloride (2905-60-4) → (2,3-dichlorophenyl)(5-methyl-6-(2-morpholinoethyl)-6H-thieno[2,3-b]pyrrol-4-yl)methanone (1327366-70-0)

Guidance literature:

4-(2-(5-methyl-6H-thieno[2,3-b]pyrrol-6-yl)ethyl)morpholine; With diethylaluminium chloride; In hexane; dichloromethane; at -78 ℃; for 0.5h;

2,3-dichlorobenzoyl chloride; In hexane; dichloromethane; at -78 - 20 ℃;

With sodium hydrogencarbonate; In hexane; dichloromethane;

Reference yield:

methyl 6H-thieno[2,3-b]pyrrole-5-carboxylate (118465-49-9) → (2,3-dichlorophenyl)(5-methyl-6-(2-morpholinoethyl)-6H-thieno[2,3-b]pyrrol-4-yl)methanone (1327366-70-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / Reflux

2.1: potassium hydroxide / water; dimethyl sulfoxide / 1.5 h / 75 °C

3.1: diethylaluminium chloride / dichloromethane; hexane / 0.5 h / -78 °C

3.2: -78 - 20 °C

With lithium aluminium tetrahydride; diethylaluminium chloride; potassium hydroxide; In tetrahydrofuran; hexane; dichloromethane; water; dimethyl sulfoxide;

upstream raw materials:

4-(2-(5-methyl-6H-thieno[2,3-b]pyrrol-6-yl)ethyl)morpholine

2,3-dichlorobenzoyl chloride

(2,3-dichlorophenyl)(5-methyl-6H-thieno[2,3-b]pyrrol-4-yI)methanone

4-(2-chloroethyl)morpholine hydrochride

Downstream raw materials:

(2-chloro-5-methyl-6-(2-morpholinoethyl)-6H-thieno[2,3-b]pyrrol-4-yl)(2,3-dichlorophenyl)methanone