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2905-60-4

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2905-60-4 Usage

General Description

2,3-Dichlorobenzoyl chloride is a chemical compound with the molecular formula C7H3Cl3O. It is a derivative of benzoyl chloride, with two chlorine atoms substituted at the 2 and 3 positions on the benzene ring. 2,3-Dichlorobenzoyl chloride is a white to pale yellow solid that is highly reactive and can release toxic fumes when exposed to water or moisture. 2,3-Dichlorobenzoyl chloride is primarily used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is also utilized in the production of polymers and other organic compounds. Due to its highly reactive nature, it must be handled and stored with extreme caution, as it can cause irritation to the skin, eyes, and respiratory system upon exposure.

Check Digit Verification of cas no

The CAS Registry Mumber 2905-60-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,0 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2905-60:
(6*2)+(5*9)+(4*0)+(3*5)+(2*6)+(1*0)=84
84 % 10 = 4
So 2905-60-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H3Cl3O/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H

2905-60-4 Well-known Company Product Price

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  • Alfa Aesar

  • (L09506)  2,3-Dichlorobenzoyl chloride, 98%   

  • 2905-60-4

  • 5g

  • 455.0CNY

  • Detail
  • Alfa Aesar

  • (L09506)  2,3-Dichlorobenzoyl chloride, 98%   

  • 2905-60-4

  • 25g

  • 1508.0CNY

  • Detail
  • Alfa Aesar

  • (L09506)  2,3-Dichlorobenzoyl chloride, 98%   

  • 2905-60-4

  • 100g

  • 4430.0CNY

  • Detail
  • Aldrich

  • (CDS001447)  2,3-Dichlorobenzoyl chloride  AldrichCPR

  • 2905-60-4

  • CDS001447-1G

  • 644.67CNY

  • Detail

2905-60-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,3-Dichlorobenzoyl chloride

1.2 Other means of identification

Product number -
Other names 2,3-dichloro-benzoyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2905-60-4 SDS

2905-60-4Relevant articles and documents

Synthesis of stable isotopically labelled versions of Lamotrigine and its methylated metabolite

Manning, Calvin O.,Wadsworth, Alan H.,Fellows, Ian

, p. 611 - 618 (2002)

Lamotrigine is a sodium channel antagonist used for the treatment of epilepsy. Synthesis of stable isotopically labelled (SIL) [M + 7] versions of Lamotrigine (1) and its N-methylated metabolite (2) are described. The routes to prepare these compounds used [M + 5] labelled [13C, 15N4]-aminoguanidine (obtained from labelled thiourea). The overall yield for the metabolite (2) was 34% from [M + 3] labelled [13C, 15N2]-thiourea. Copyright

Synthesis and anti-rheumatoid arthritis activities of 3-(4-aminophenyl)-coumarin derivatives

Miao, Yuhang,Yang, Jie,Yun, Yinling,Sun, Jie,Wang, Xiaojing

, p. 450 - 461 (2021/02/19)

Rheumatoid arthritis is a chronic systemic disease characterised by an unknown aetiology of inflammatory synovitis. A large number of studies have shown that synoviocytes show tumour-like dysplasia in the pathological process of RA, and the changes in the expression of related cytokines are closely related to the pathogenesis of RA. In this thesis, a series of novel 3-(4-aminophenyl) coumarins containing different substituents were synthesised to find new coumarin anti-inflammatory drugs for the treatment of rheumatoid arthritis. The results of preliminary activity screening showed that compound 5e had the strongest inhibitory activity on the proliferation of fibroid synovial cells, and it also had inhibitory effect on RA-related cytokines IL-1, IL-6, and TNF-α. The preliminary mechanism study showed that compound 5e could inhibit the activation of NF-κB and MAPKs signal pathway. The anti-inflammatory activity of compound 5ein?vivo was further determined in the rat joint inflammation model.

Synthesis and biological evaluation of 3–(4-aminophenyl)-coumarin derivatives as potential anti-Alzheimer’s disease agents

Hu, Yu-Heng,Yang, Jie,Zhang, Yun,Liu, Ke-Chun,Liu, Teng,Sun, Jie,Wang, Xiao-Jing

, p. 1083 - 1092 (2019/06/06)

The work is focused on the design of drugs that prevent and treat Alzheimer’s disease (AD) and its complications. A series of 3–(4-aminophenyl)-coumarin derivatives designed, synthesised, fully characterised and evaluated in vitro/vivo. The biological assay experiments showed that some compounds displayed a clearly selective inhibition for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Among all compounds, compound 4m exhibited the highest AChE inhibition with an IC50 value of 0.091 ± 0.011 μM and compound 4k exhibited the highest BuChE inhibition with an IC50 value of 0.559 ± 0.017 μM. A zebrafish behaviour analyser (Zebrobox) was used to determine the behavioural effects of the active compound on the movement distance of the aluminium chloride-induced zebrafish. Compound 4m offered a potential drug design concept for the development of therapeutic or preventive agents for AD and its complications.

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