(S)-2-[(2,7-Dichloro-fluoren-9-ylidenemethyl)-amino]-3-phenyl-propionic acid 4-nitro-phenyl ester

Base Information

Chemical Name:(S)-2-[(2,7-Dichloro-fluoren-9-ylidenemethyl)-amino]-3-phenyl-propionic acid 4-nitro-phenyl ester
CAS No.:122236-94-6
Molecular Formula:C₂₉H₂₀Cl₂N₂O₄
Molecular Weight:531.395
Hs Code.:

Synonyms:(S)-2-[(2,7-Dichloro-fluoren-9-ylidenemethyl)-amino]-3-phenyl-propionic acid 4-nitro-phenyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-[(2,7-Dichloro-fluoren-9-ylidenemethyl)-amino]-3-phenyl-propionic acid 4-nitro-phenyl ester

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Technology Process of (S)-2-[(2,7-Dichloro-fluoren-9-ylidenemethyl)-amino]-3-phenyl-propionic acid 4-nitro-phenyl ester

There total 4 articles about (S)-2-[(2,7-Dichloro-fluoren-9-ylidenemethyl)-amino]-3-phenyl-propionic acid 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 122236-89-9
DC-FM-bar-Phe-OH

: 122236-94-6
(S)-2-[(2,7-Dichloro-fluoren-9-ylidenemethyl)-amino]-3-phenyl-propionic acid 4-nitro-phenyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; 1.) 0 deg C, 3 h, 2.) RT, 2 h;
DOI:10.1021/jo00279a015

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 122236-94-6
(S)-2-[(2,7-Dichloro-fluoren-9-ylidenemethyl)-amino]-3-phenyl-propionic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80.5 percent / NaOH / methanol / 6 h / Heating

2: 79 percent / dicyclohexylcarbodiimide (DCC) / tetrahydrofuran / 1.) 0 deg C, 3 h, 2.) RT, 2 h

With sodium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;
DOI:10.1021/jo00279a015

Reference yield:

: 7012-16-0
2,7-dichloro-9H-fluorene

: 122236-94-6
(S)-2-[(2,7-Dichloro-fluoren-9-ylidenemethyl)-amino]-3-phenyl-propionic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / EtOK / diethyl ether / 3 h / Heating

2: 80.5 percent / NaOH / methanol / 6 h / Heating

3: 79 percent / dicyclohexylcarbodiimide (DCC) / tetrahydrofuran / 1.) 0 deg C, 3 h, 2.) RT, 2 h

With sodium hydroxide; potassium ethoxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jo00279a015