(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(4-methoxyphenylamino)-3-phenylpropanoate

Base Information

• Chemical Name: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(4-methoxyphenylamino)-3-phenylpropanoate
• CAS No.: 710293-16-6
• Molecular Formula: C₂₆H₃₅NO₃
• Molecular Weight: 409.569
• Mol file: 710293-16-6.mol

Synonyms:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(4-methoxyphenylamino)-3-phenylpropanoate

Chemical Property of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(4-methoxyphenylamino)-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(4-methoxyphenylamino)-3-phenylpropanoate

There total 1 articles about (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(4-methoxyphenylamino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

L-menthyl acetate (2623-23-6) + 4-methoxy-N-[(E)-phenylmethylidene]aniline (1613-90-7) → (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(4-methoxyphenylamino)-3-phenylpropanoate + (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(4-methoxyphenylamino)-3-phenylpropanoate (710293-16-6)

Guidance literature:

L-menthyl acetate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

4-methoxy-N-[(E)-phenylmethylidene]aniline; In tetrahydrofuran; at -78 - -30 ℃;

DOI:10.1021/ol049675n

Reference yield:

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(4-methoxyphenylamino)-3-phenylpropanoate (710293-16-6) → (R)-3-(4-Methoxy-phenylamino)-3-phenyl-propionic acid

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/ol049675n

Reference yield:

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 3-(4-methoxyphenylamino)-3-phenylpropanoate (710293-16-6) → methyl (R)-(+)-3-(4-methoxyphenylamino)-3-phenylpropanoate (188488-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: n-Bu₄N⁽¹⁺⁾*OH^(1-) / tetrahydrofuran / 1 h / 0 °C

2: 320 mg / hexane; methanol / 20 °C

With tetra(n-butyl)ammonium hydroxide; In tetrahydrofuran; methanol; hexane;

DOI:10.1021/ol049675n

upstream raw materials:

L-menthyl acetate

4-methoxy-N-[(E)-phenylmethylidene]aniline

Downstream raw materials:

methyl (R)-(+)-3-(4-methoxyphenylamino)-3-phenylpropanoate