4-[1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluoro-N-(4-fluorophenyl)benzamide

Base Information

Chemical Name:4-[1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluoro-N-(4-fluorophenyl)benzamide
CAS No.:1402582-05-1
Molecular Formula:C₂₇H₂₀ClF₅N₄O₂
Molecular Weight:562.926
Hs Code.:

Synonyms:4-[1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluoro-N-(4-fluorophenyl)benzamide

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Chemical Property of 4-[1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluoro-N-(4-fluorophenyl)benzamide

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Technology Process of 4-[1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluoro-N-(4-fluorophenyl)benzamide

There total 12 articles about 4-[1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluoro-N-(4-fluorophenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₁₅Cl₂F₄N₃O₂

: 371-40-4
4-fluoroaniline

: 1402582-05-1
4-[1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluoro-N-(4-fluorophenyl)benzamide

Guidance literature:: With triethylamine; In acetonitrile; at 23 ℃; for 2h;

Reference yield:

: 95037-98-2
ethyl 2-(4-amino-3-fluorophenyl)propionate

: 1402582-05-1
4-[1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluoro-N-(4-fluorophenyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid; potassium iodide; sodium nitrite / water / 0 - 23 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 8 h / Reflux

3: lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 40 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 23 °C

5: ethanol; sodium hydroxide / 100 °C

6: thionyl chloride / dichloromethane / 2 h / Reflux

7: triethylamine / acetonitrile / 2 h / 23 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; lithium hydroxide monohydrate; ethanol; sulfuric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1402585-18-5
ethyl 2-(3-fluoro-4-iodophenyl)propanoate

: 1402582-05-1
4-[1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluoro-N-(4-fluorophenyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 8 h / Reflux

2: lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 40 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 23 °C

4: ethanol; sodium hydroxide / 100 °C

5: thionyl chloride / dichloromethane / 2 h / Reflux

6: triethylamine / acetonitrile / 2 h / 23 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; lithium hydroxide monohydrate; ethanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;