N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4R)-4-<(methylsulfonyl)oxy>-L-proline ethyl ester

Base Information

• Chemical Name: N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4R)-4-<(methylsulfonyl)oxy>-L-proline ethyl ester
• CAS No.: 126294-84-6
• Molecular Formula: C₂₆H₃₅Cl₃N₂O₁₀S
• Molecular Weight: 673.996

Synonyms:N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4R)-4-<(methylsulfonyl)oxy>-L-proline ethyl ester

Chemical Property of N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4R)-4-<(methylsulfonyl)oxy>-L-proline ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4R)-4-<(methylsulfonyl)oxy>-L-proline ethyl ester

There total 2 articles about N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4R)-4-<(methylsulfonyl)oxy>-L-proline ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine (92893-50-0) → N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4R)-4-<(methylsulfonyl)oxy>-L-proline ethyl ester (126294-84-6)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 3.5 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / 0 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm00168a013

Reference yield:

(S)-2-[((S)-1-Chlorocarbonyl-ethyl)-(2,2,2-trichloro-ethoxycarbonyl)-amino]-4-phenyl-butyric acid ethyl ester (92893-51-1) → N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4R)-4-<(methylsulfonyl)oxy>-L-proline ethyl ester (126294-84-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / Ambient temperature

2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

With triethylamine; In dichloromethane;

DOI:10.1021/jm00168a013

Reference yield: 94.0%

N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4R)-4-<(methylsulfonyl)oxy>-L-proline ethyl ester (126294-84-6) → N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-azido-L-proline ethyl ester (126257-61-2)

Guidance literature:

With sodium azide; In ethanol; water; for 24h; Heating;

DOI:10.1021/jm00168a013

upstream raw materials:

N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-N-(2,2,2-trichloroethoxycarbonyl)-L-alanine

(S)-2-[((S)-1-Chlorocarbonyl-ethyl)-(2,2,2-trichloro-ethoxycarbonyl)-amino]-4-phenyl-butyric acid ethyl ester

Downstream raw materials:

N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-azido-L-proline ethyl ester

N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-amino-L-proline ethyl ester

N--L-alanyl>-(4S)-4-<<<6-chloro-1,2,4-benzothiadiazin-7-yl>sulfonyl>amino>-L-proline ethyl ester S,S-dioxide

N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-(4S)-4-<<<6-chloro-1,2,4-benzothiadiazin-7-yl>sulfonyl>amino>-L-proline ethyl ester S,S-dioxide

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