ethyl 5-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1-methyl-1H-indole-2-carboxylate

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Chemical Name:ethyl 5-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1-methyl-1H-indole-2-carboxylate
CAS No.:1314128-02-3
Molecular Formula:C₂₄H₂₅FN₂O₅
Molecular Weight:440.471
Hs Code.:

Synonyms:ethyl 5-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1-methyl-1H-indole-2-carboxylate

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Chemical Property of ethyl 5-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1-methyl-1H-indole-2-carboxylate

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Technology Process of ethyl 5-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1-methyl-1H-indole-2-carboxylate

There total 6 articles about ethyl 5-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1-methyl-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1224719-48-5
2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoic acid

: 71056-58-1
5-amino-1-methyl-1H-indole-2-carboxylic acid ethyl ester

: 1314128-02-3
ethyl 5-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1-methyl-1H-indole-2-carboxylate

Guidance literature:: 2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 2h;

5-amino-1-methyl-1H-indole-2-carboxylic acid ethyl ester; With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 87392-07-2
(S)-tetrahydro-2-furoic acid

: 1314128-02-3
ethyl 5-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1-methyl-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 11 h / 22 - 75 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 10 °C

2.2: 2 - 4 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2 h / 0 - 20 °C

3.2: 3 h / 60 °C

3.3: 0 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

4.2: 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; sulfuric acid; triphenylphosphine; diethylazodicarboxylate; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;

Reference yield:

: 65145-13-3
2-fluoro-4-hydroxybenzoic acid

: 1314128-02-3
ethyl 5-[({2-fluoro-4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1-methyl-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 16 h / 90 °C

2.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2 h / 0 - 20 °C

2.2: 3 h / 60 °C

2.3: 0 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

3.2: 20 °C

With oxalyl dichloride; sulfuric acid; triphenylphosphine; diethylazodicarboxylate; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;