methyl 2-(8-chloro-3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-chlorophenyl)acetate

Base Information

• Chemical Name: methyl 2-(8-chloro-3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-chlorophenyl)acetate
• CAS No.: 1413931-02-8
• Molecular Formula: C₂₄H₁₇Cl₃N₂O₄
• Molecular Weight: 503.769
• Mol file: 1413931-02-8.mol

Synonyms:methyl 2-(8-chloro-3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-chlorophenyl)acetate

Chemical Property of methyl 2-(8-chloro-3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-chlorophenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(8-chloro-3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-chlorophenyl)acetate

There total 3 articles about methyl 2-(8-chloro-3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-chlorophenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C30H22Cl3N3O6 → methyl 2-(8-chloro-3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-chlorophenyl)acetate (1413931-02-8)

Guidance literature:

With iron; In acetic acid; at 50 - 70 ℃; for 1h;

DOI:10.1016/j.ejmech.2012.08.003

Reference yield:

4-chloro-2-nitro-benzoic acid (6280-88-2) → methyl 2-(8-chloro-3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-chlorophenyl)acetate (1413931-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 0.17 h / 20 °C

1.2: 24 h / 0 - 20 °C

2.1: iron / acetic acid / 1 h / 50 - 70 °C

With iron; potassium hydroxide; In methanol; acetic acid; 1.1: |Ugi Condensation;

DOI:10.1016/j.ejmech.2012.08.003

Reference yield:

para-chlorobenzoic acid (74-11-3) → methyl 2-(8-chloro-3-(4-chlorophenyl)-2,5-dioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-chlorophenyl)acetate (1413931-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 0.17 h / 20 °C

1.2: 24 h / 0 - 20 °C

2.1: iron / acetic acid / 1 h / 50 - 70 °C

With iron; potassium hydroxide; In methanol; acetic acid; 1.1: |Ugi Condensation;

DOI:10.1016/j.ejmech.2012.08.003

upstream raw materials:

4-chloro-2-nitro-benzoic acid

para-chlorobenzoic acid

Downstream raw materials:

methyl 2-(8-chloro-3-(4-chlorophenyl)-5-oxo-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-chlorophenyl)acetate

methyl 2-(8-chloro-3-(4-chlorophenyl)-2-(methylthio)-5-oxo-3H-benzo[e][1,4]diazepin-4(5H)-yl)-2-(4-chlorophenyl)acetate