N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-hydroxyethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-hydroxyethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1426448-29-4
Molecular Formula:C₂₄H₂₃F₂N₅O₄
Molecular Weight:483.475
Hs Code.:

Synonyms:N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-hydroxyethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-hydroxyethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-hydroxyethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

There total 12 articles about N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-hydroxyethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3-((5-(5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)carbamoyl)imidazo[1,2-a]pyridin-6-yl)methyl methanesulfonate

: 107-21-1
ethylene glycol

: 1426448-29-4
N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-hydroxyethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: With potassium carbonate; at 80 ℃; for 0.333333h;

Reference yield:

: 936637-99-9
ethyl 6-(hydroxymethyl)imidazo[1,2-a]pyridine-3-carboxylate

: 1426448-29-4
N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-hydroxyethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 1H-imidazole; dmap / dichloromethane / 20 °C

2: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 20 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.25 h / 20 °C

4: pyridine / 0.33 h / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

7: potassium carbonate / 0.33 h / 80 °C

With pyridine; 1H-imidazole; dmap; oxalyl dichloride; tetrabutyl ammonium fluoride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1426449-78-6
N-(5-(5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)-6-(((triisopropylsilyl)oxy)methyl)imidazo[1,2-a]pyridine-3-carboxamide

: 1426448-29-4
N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-hydroxyethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

3: potassium carbonate / 0.33 h / 80 °C

With tetrabutyl ammonium fluoride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;