Technology Process of 6-methyl-4,7-bis(o-tolyl)isatin
There total 6 articles about 6-methyl-4,7-bis(o-tolyl)isatin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; cesium fluoride;
In
1,2-dimethoxyethane; water;
Reflux;
DOI:10.1039/c4ob00552j
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sulfuric acid / 35 °C
2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; cesium fluoride / water; 1,2-dimethoxyethane / Reflux
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sulfuric acid; palladium diacetate; cesium fluoride;
In
1,2-dimethoxyethane; water;
2: |Suzuki Coupling;
DOI:10.1039/c4ob00552j
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid; tetrafluoroboric acid; isopentyl nitrite / diethyl ether / 0.5 h / 5 - 25 °C
1.2: 0.5 h
2.1: iron; calcium chloride / ethanol; water / 6 h
3.1: hydroxylamine hydrochloride; hydrogenchloride / water; 1,4-dioxane
4.1: sulfuric acid / 35 °C
5.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; cesium fluoride / water; 1,2-dimethoxyethane / Reflux
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; tetrafluoroboric acid; sulfuric acid; hydroxylamine hydrochloride; palladium diacetate; iron; acetic acid; cesium fluoride; calcium chloride; isopentyl nitrite;
In
1,4-dioxane; 1,2-dimethoxyethane; diethyl ether; ethanol; water;
5.1: |Suzuki Coupling;
DOI:10.1039/c4ob00552j
