3-amino-6-(4-chloro-3-(N-m-tolylsulfamoyl)phenyl)-N-methylpyrazine-2-carboxamide

Base Information

Chemical Name:3-amino-6-(4-chloro-3-(N-m-tolylsulfamoyl)phenyl)-N-methylpyrazine-2-carboxamide
CAS No.:1377550-72-5
Molecular Formula:C₁₉H₁₈ClN₅O₃S
Molecular Weight:431.903
Hs Code.:

Synonyms:3-amino-6-(4-chloro-3-(N-m-tolylsulfamoyl)phenyl)-N-methylpyrazine-2-carboxamide

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Chemical Property of 3-amino-6-(4-chloro-3-(N-m-tolylsulfamoyl)phenyl)-N-methylpyrazine-2-carboxamide

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Technology Process of 3-amino-6-(4-chloro-3-(N-m-tolylsulfamoyl)phenyl)-N-methylpyrazine-2-carboxamide

There total 5 articles about 3-amino-6-(4-chloro-3-(N-m-tolylsulfamoyl)phenyl)-N-methylpyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: C₁₉H₂₃BClNO₄S

: 146940-37-6
3-amino-6-bromo-N-methylpyrazine-2-carboxamide

: 1377550-72-5
3-amino-6-(4-chloro-3-(N-m-tolylsulfamoyl)phenyl)-N-methylpyrazine-2-carboxamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In water; N,N-dimethyl-formamide; at 20 - 85 ℃; for 2h;
DOI:10.1021/jm300403a

Reference yield:

: 60811-17-8
5-bromo-2-chloroaniline

: 1377550-72-5
3-amino-6-(4-chloro-3-(N-m-tolylsulfamoyl)phenyl)-N-methylpyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

1.2: 2.25 h / 0 - 20 °C

2.1: pyridine / dichloromethane / 0.5 h

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 3 h / 90 °C / sealed tube

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / water; N,N-dimethyl-formamide / 2 h / 20 - 85 °C

With pyridine; hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; triethylamine; sodium nitrite; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 3.1: Suzuki-Miyaura cross-coupling / 4.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300403a

Reference yield:

: 5-bromo-2-chloro-N-m-tolylbenzenesulfonamide

: 1377550-72-5
3-amino-6-(4-chloro-3-(N-m-tolylsulfamoyl)phenyl)-N-methylpyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 3 h / 90 °C / sealed tube

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / water; N,N-dimethyl-formamide / 2 h / 20 - 85 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: Suzuki-Miyaura cross-coupling / 2: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300403a