ethyl 3-(2-phenylsulfonylmethylphenyl)-1,4-dihydroxynaphthalene-2-carboxylate

Base Information

• Chemical Name: ethyl 3-(2-phenylsulfonylmethylphenyl)-1,4-dihydroxynaphthalene-2-carboxylate
• CAS No.: 1021499-77-3
• Molecular Formula: C₂₆H₂₂O₆S
• Molecular Weight: 462.523
• Mol file: 1021499-77-3.mol

Synonyms:ethyl 3-(2-phenylsulfonylmethylphenyl)-1,4-dihydroxynaphthalene-2-carboxylate

Chemical Property of ethyl 3-(2-phenylsulfonylmethylphenyl)-1,4-dihydroxynaphthalene-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(2-phenylsulfonylmethylphenyl)-1,4-dihydroxynaphthalene-2-carboxylate

There total 2 articles about ethyl 3-(2-phenylsulfonylmethylphenyl)-1,4-dihydroxynaphthalene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl 3-(2-phenylsulfonylmethylphenyl)acrylate (1021499-76-2) + 3-(phenylsulfanyl)isobenzofuran-1(3H)-one (51287-54-8) → ethyl 3-(2-phenylsulfonylmethylphenyl)-1,4-dihydroxynaphthalene-2-carboxylate (1021499-77-3)

Guidance literature:

3-(phenylsulfanyl)isobenzofuran-1(3H)-one; With lithium tert-butoxide; In tetrahydrofuran; at -60 ℃; for 0.416667h;

ethyl 3-(2-phenylsulfonylmethylphenyl)acrylate; In tetrahydrofuran; at -60 - 20 ℃; Further stages.;

DOI:10.1016/j.tet.2008.01.039

Reference yield: 81.0%

ethyl 3-(2-phenylsulfonylmethylphenyl)acrylate (1021499-76-2) + 3-phenylsulfonylphthalide (65131-08-0) → ethyl 3-(2-phenylsulfonylmethylphenyl)-1,4-dihydroxynaphthalene-2-carboxylate (1021499-77-3)

Guidance literature:

3-phenylsulfonylphthalide; With lithium tert-butoxide; In tetrahydrofuran; at -60 ℃; for 0.416667h;

ethyl 3-(2-phenylsulfonylmethylphenyl)acrylate; In tetrahydrofuran; at -60 - 20 ℃; Further stages.;

DOI:10.1016/j.tet.2008.01.039

Reference yield: 92.0%

ethyl 3-(2-phenylsulfonylmethylphenyl)-1,4-dihydroxynaphthalene-2-carboxylate (1021499-77-3) + dimethyl sulfate (77-78-1) → ethyl 3-(2-phenylsulfonylmethylphenyl)-1,4-dimethoxynaphthalene-2-carboxylate (1021499-78-4)

Guidance literature:

With potassium carbonate; In acetone; for 2h; Heating;

DOI:10.1016/j.tet.2008.01.039

upstream raw materials:

ethyl 3-(2-phenylsulfonylmethylphenyl)acrylate

3-(phenylsulfanyl)isobenzofuran-1(3H)-one

3-phenylsulfonylphthalide

Downstream raw materials:

ethyl 3-(2-benzenesulfonylmethylphenyl)-1,4-naphthoquinone-2-carboxylate

ethyl 3-(2-phenylsulfonylmethylphenyl)-1,4-dimethoxynaphthalene-2-carboxylate