(3S,4S)-1-(4-iodophenyl)-3,4-bis(trifluoromethanesulfonyloxy)pyrrolidine

Base Information

Chemical Name:(3S,4S)-1-(4-iodophenyl)-3,4-bis(trifluoromethanesulfonyloxy)pyrrolidine
CAS No.:871822-38-7
Molecular Formula:C₁₂H₁₀F₆INO₆S₂
Molecular Weight:569.241
Hs Code.:

Synonyms:(3S,4S)-1-(4-iodophenyl)-3,4-bis(trifluoromethanesulfonyloxy)pyrrolidine

Suppliers and Price of (3S,4S)-1-(4-iodophenyl)-3,4-bis(trifluoromethanesulfonyloxy)pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4S)-1-(4-iodophenyl)-3,4-bis(trifluoromethanesulfonyloxy)pyrrolidine

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Technology Process of (3S,4S)-1-(4-iodophenyl)-3,4-bis(trifluoromethanesulfonyloxy)pyrrolidine

There total 2 articles about (3S,4S)-1-(4-iodophenyl)-3,4-bis(trifluoromethanesulfonyloxy)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 871822-36-5
(3S,4S)-1-(4-iodophenyl)pyrrolidine-3,4-diol

: 358-23-6
trifluoromethylsulfonic anhydride

: 871822-38-7
(3S,4S)-1-(4-iodophenyl)-3,4-bis(trifluoromethanesulfonyloxy)pyrrolidine

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jo0513414

Reference yield:

: 540-37-4
p-aminoiodobenzene

: 871822-38-7
(3S,4S)-1-(4-iodophenyl)-3,4-bis(trifluoromethanesulfonyloxy)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 34 percent / potassium carbonate; 18-crown-6 / dimethylformamide / 216 h / 90 °C

2: 37 percent / triethylamine / CH₂Cl₂ / 16 h / 20 °C

With 18-crown-6 ether; potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo0513414