9BETA,11ALPHA,15S-TRIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, TRIS (HYDROXYMETHYL)AMINOMETHANE SALT

Base Information

• Chemical Name: 9BETA,11ALPHA,15S-TRIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, TRIS (HYDROXYMETHYL)AMINOMETHANE SALT
• CAS No.: 89847-02-9
• Molecular Formula: C₄H₁₁NO₃*C₂₀H₃₄O₅
• Molecular Weight: 475.623
• Mol file: 89847-02-9.mol

Synonyms:9BETA-PGF2ALPHA (TROMETHAMINE SALT);9BETA,11ALPHA,15S-TRIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, TRIS (HYDROXYMETHYL)AMINOMETHANE SALT;PROSTAGLANDIN F2BETA TROMETHAMINE SALT

Chemical Property of 9BETA,11ALPHA,15S-TRIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, TRIS (HYDROXYMETHYL)AMINOMETHANE SALT

Chemical Property:

• PSA: 184.70000
• LogP: 1.40400

Purity/Quality:

99% ^*data from raw suppliers

Prostaglandin F2β (tromethamine salt) ≥99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Prostaglandin F2β (PGF2β) (tromethamine salt) is a derivative of PGF2β with increased water solubility. PGF2β is the 9β-hydroxy stereoisomer of PGF2α . It is much less active than PGF2α in antifertility and bronchoconstrictor activities. PGF2β exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of PGF2α.

Technology Process of 9BETA,11ALPHA,15S-TRIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, TRIS (HYDROXYMETHYL)AMINOMETHANE SALT

There total 17 articles about 9BETA,11ALPHA,15S-TRIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, TRIS (HYDROXYMETHYL)AMINOMETHANE SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

dinoprost (551-11-1) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → dinoprost tromethamine (38562-01-5,89847-02-9)

Guidance literature:

dinoprost; In acetonitrile; at 43 - 47 ℃; for 0.25h;

2-amino-2-hydroxymethyl-1,3-propanediol; In water; acetonitrile; at 53 - 57 ℃; for 0.0833333h;

Reference yield:

→ dinoprost (551-11-1) + dinoprost tromethamine (38562-01-5,89847-02-9)

Guidance literature:

Reference yield:

(S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-(2-methylphenyl)ureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-phenylpropionic acid (306768-49-0) → dinoprost tromethamine (38562-01-5,89847-02-9)

Guidance literature:

upstream raw materials:

(S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-(2-methylphenyl)ureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-phenylpropionic acid

(S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-phenylureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-(4-methoxyphenyl)propionic acid

(S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-phenylureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-(2,4-dimethoxyphenyl)propionic acid

(3S)-(3,4-dimethoxyphenyl)-3-[(2S)-{2,4-dioxo-1-[4-(3-phenylureido)benzyl]-1,3-diazaspiro[4.5]dec-3-yl}-4-methylpentanoylamino]propionic acid