C₄₁H₄₅N₅O₁₀

Base Information

• Chemical Name: C₄₁H₄₅N₅O₁₀
• CAS No.: 1374031-89-6
• Molecular Formula: C₄₁H₄₅N₅O₁₀
• Molecular Weight: 767.836
• Mol file: 1374031-89-6.mol

Synonyms:C₄₁H₄₅N₅O₁₀

Chemical Property of C₄₁H₄₅N₅O₁₀

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₁H₄₅N₅O₁₀

There total 3 articles about C₄₁H₄₅N₅O₁₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

C47H59N5O10Si (1374031-88-5) → C41H45N5O10 (1374031-89-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1135/cccc2011090

Reference yield:

3'-tert-butyldimethylsilylthymidine 5'-carboxaldehyde (131118-61-1) → C41H45N5O10 (1374031-89-6)

Guidance literature:

Multi-step reaction with 3 steps

1: magnesium sulfate / tetrahydrofuran / 20 °C

2: sodium tris(acetoxy)borohydride / ethanol / 2 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; magnesium sulfate; In tetrahydrofuran; ethanol;

DOI:10.1135/cccc2011090

Reference yield:

3'-O-(t-butyldimethylsilyl)thymidine (40733-27-5) → C41H45N5O10 (1374031-89-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

1.2: 0.5 h / -78 - 20 °C

2.1: magnesium sulfate / tetrahydrofuran / 20 °C

3.1: sodium tris(acetoxy)borohydride / ethanol / 2 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With oxalyl dichloride; tetrabutyl ammonium fluoride; sodium tris(acetoxy)borohydride; magnesium sulfate; dimethyl sulfoxide; In tetrahydrofuran; ethanol; dichloromethane; 1.1: Swern oxidation / 1.2: Swern oxidation;

DOI:10.1135/cccc2011090

upstream raw materials:

C₄₇H₅₉N₅O₁₀Si

3'-tert-butyldimethylsilylthymidine 5'-carboxaldehyde

3'-O-(t-butyldimethylsilyl)thymidine

Downstream raw materials:

C₅₀H₆₂N₇O₁₁P