[(1-methyl)ethoxycarbonyloxy]methyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate

Base Information

Chemical Name:[(1-methyl)ethoxycarbonyloxy]methyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate
CAS No.:1268602-80-7
Molecular Formula:C₂₄H₂₄ClNO₇
Molecular Weight:473.91
Hs Code.:

Synonyms:[(1-methyl)ethoxycarbonyloxy]methyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate

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Chemical Property of [(1-methyl)ethoxycarbonyloxy]methyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate

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Technology Process of [(1-methyl)ethoxycarbonyloxy]methyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate

There total 2 articles about [(1-methyl)ethoxycarbonyloxy]methyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

: 258841-42-8
isopropyloxycarbonyloxymethyl iodide

: 53-86-1
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

: 1268602-80-7
[(1-methyl)ethoxycarbonyloxy]methyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate

Guidance literature:: [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid; With N,N,N',N'-tetramethylguanidine; In N,N-dimethyl acetamide; at -15 ℃; Inert atmosphere;

isopropyloxycarbonyloxymethyl iodide; In N,N-dimethyl acetamide; at -15 ℃; Inert atmosphere;
DOI:10.1021/jm101085j

Reference yield:

: 35180-01-9
chloromethyl isopropyl carbonate

: 1268602-80-7
[(1-methyl)ethoxycarbonyloxy]methyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 18-crown-6 ether; sodium iodide / toluene / 105 - 112 °C / Inert atmosphere

2.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl acetamide / -15 °C / Inert atmosphere

2.2: -15 °C / Inert atmosphere

With 18-crown-6 ether; sodium iodide; N,N,N',N'-tetramethylguanidine; In N,N-dimethyl acetamide; toluene;
DOI:10.1021/jm101085j