258841-42-8Relevant articles and documents
Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs
Coughlin, John E.,Padmanabhan, Seetharamaiyer,Zhang, Guangrong,Kirk, Cassandra J.,Govardhan, Chandrika P.,Korba, Brent E.,O'Loughlin, Kathleen,Green, Carol E.,Mirsalis, Jon,Morrey, John D.,Iyer, Radhakrishnan P.
, p. 1783 - 1786 (2010)
The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs for further therapeutic development against the hepatitis B virus (HBV).
COMPOUNDS FOR TREATING CANCER
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Paragraph 0237; 0238, (2020/11/23)
Provided herein are prodrugs of 5-fluorodeoxyuridine monophosphate compounds, compositions thereof, methods of their preparation, and their use in treating cancers. In another aspect, provided herein is a pharmaceutical composition comprising any compound disclosed herein, or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier, diluent, and excipient.
PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF
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Paragraph 0447; 2448; 0449; 0450, (2016/05/02)
The present invention relates to a phenol derivative and the preparation method and use in medicine thereof, and particular to a phenol derivative represented by general formula (A) or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically