(R)-2-(benzyloxycarbonylamino )-3-((R)-2,3-bis(octylcarbamoyloxy)propylthio)propanoic acid

Base Information

Chemical Name:(R)-2-(benzyloxycarbonylamino )-3-((R)-2,3-bis(octylcarbamoyloxy)propylthio)propanoic acid
CAS No.:1337527-63-5
Molecular Formula:C₃₂H₅₃N₃O₈S
Molecular Weight:639.854
Hs Code.:

Synonyms:(R)-2-(benzyloxycarbonylamino )-3-((R)-2,3-bis(octylcarbamoyloxy)propylthio)propanoic acid

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Chemical Property of (R)-2-(benzyloxycarbonylamino )-3-((R)-2,3-bis(octylcarbamoyloxy)propylthio)propanoic acid

Chemical Property:

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Technology Process of (R)-2-(benzyloxycarbonylamino )-3-((R)-2,3-bis(octylcarbamoyloxy)propylthio)propanoic acid

There total 5 articles about (R)-2-(benzyloxycarbonylamino )-3-((R)-2,3-bis(octylcarbamoyloxy)propylthio)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1337527-62-4
(R)-tert-butyl 2-(benzyloxycarbonylamino)-3-((R)-2,3-bis(octylcarbamoyloxy)propylthio)propanoate

: 1337527-63-5
(R)-2-(benzyloxycarbonylamino )-3-((R)-2,3-bis(octylcarbamoyloxy)propylthio)propanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1337527-63-5
(R)-2-(benzyloxycarbonylamino )-3-((R)-2,3-bis(octylcarbamoyloxy)propylthio)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 25 °C

2.1: triethylamine; 1,4-dithio-erythritol / dichloromethane / 1.5 h / 20 °C

3.1: sodium hydroxide / tert-butyl alcohol / 0.5 h / 20 °C

3.2: 15 h / 20 °C

4.1: dmap / benzene / 20 - 40 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With dmap; 1,4-dithio-erythritol; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In dichloromethane; tert-butyl alcohol; benzene;

Reference yield:

: 105729-42-8
N,N'-bis(carbobenzyloxy)-L-cystine di-tert-butyl ester

: 1337527-63-5
(R)-2-(benzyloxycarbonylamino )-3-((R)-2,3-bis(octylcarbamoyloxy)propylthio)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; 1,4-dithio-erythritol / dichloromethane / 1.5 h / 20 °C

2.1: sodium hydroxide / tert-butyl alcohol / 0.5 h / 20 °C

2.2: 15 h / 20 °C

3.1: dmap / benzene / 20 - 40 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With dmap; 1,4-dithio-erythritol; triethylamine; trifluoroacetic acid; sodium hydroxide; In dichloromethane; tert-butyl alcohol; benzene;