3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-(dimethylamino)-2-oxoethoxy)-2,6-difluorobenzamide

Base Information

Chemical Name:3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-(dimethylamino)-2-oxoethoxy)-2,6-difluorobenzamide
CAS No.:1403883-91-9
Molecular Formula:C₂₀H₁₆ClF₂N₃O₃S
Molecular Weight:451.881
Hs Code.:

Synonyms:3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-(dimethylamino)-2-oxoethoxy)-2,6-difluorobenzamide

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Chemical Property of 3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-(dimethylamino)-2-oxoethoxy)-2,6-difluorobenzamide

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Technology Process of 3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-(dimethylamino)-2-oxoethoxy)-2,6-difluorobenzamide

There total 4 articles about 3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-(dimethylamino)-2-oxoethoxy)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 951122-37-5
2,6-difluoro-3-hydroxy-benzamide

: 1403884-17-2
2-bromo-2-(4-(4-chlorophenyl)thiazol-2-yl)-N,N-dimethylacetamide

: 1403883-91-9
3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-(dimethylamino)-2-oxoethoxy)-2,6-difluorobenzamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 17969-44-7
2-(4-(4-chlorophenyl)thiazol-2-yl)acetic acid

: 1403883-91-9
3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-(dimethylamino)-2-oxoethoxy)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 4 h / 20 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 0.5 h / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 679802-69-8
2-(4-(4-chlorophenyl)thiazol-2-yl)-N,N-dimethylacetamide

: 1403883-91-9
3-(1-(4-(4-chlorophenyl)thiazol-2-yl)-2-(dimethylamino)-2-oxoethoxy)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 0.5 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrachloromethane; N,N-dimethyl-formamide;