tert-butyl phenylacetyl-[2-(2-phenylsulfanyl-1H-indol-3-yl)ethyl]carbamate

Base Information

Chemical Name:tert-butyl phenylacetyl-[2-(2-phenylsulfanyl-1H-indol-3-yl)ethyl]carbamate
CAS No.:712273-36-4
Molecular Formula:C₂₉H₃₀N₂O₃S
Molecular Weight:486.635
Hs Code.:

Synonyms:tert-butyl phenylacetyl-[2-(2-phenylsulfanyl-1H-indol-3-yl)ethyl]carbamate

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Chemical Property of tert-butyl phenylacetyl-[2-(2-phenylsulfanyl-1H-indol-3-yl)ethyl]carbamate

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Technology Process of tert-butyl phenylacetyl-[2-(2-phenylsulfanyl-1H-indol-3-yl)ethyl]carbamate

There total 6 articles about tert-butyl phenylacetyl-[2-(2-phenylsulfanyl-1H-indol-3-yl)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 712273-33-1
naphthalen-2-yl-methyl 3-[2-(t-butoxycarbonyl-phenylacetyl-amino)-ethyl]-2-phenyl-sulfanyl-indole-1-carboxylate

: 712273-36-4
tert-butyl phenylacetyl-[2-(2-phenylsulfanyl-1H-indol-3-yl)ethyl]carbamate

Guidance literature:: With hydrogen; palladium dihydroxide; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ol0493406

Reference yield:

: 61-54-1
tryptamine

: 712273-36-4
tert-butyl phenylacetyl-[2-(2-phenylsulfanyl-1H-indol-3-yl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / ethyldiisopropylamine / tetrahydrofuran / 0.5 h

2: 84 percent / hydrochloric acid / dioxane / 0.08 h

3: 69 percent / NaH; 4-(dimethylamino)pyridine / tetrahydrofuran / 5 h

4: 90 percent / lithium hexamethyldisilazide; 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 20 °C

5: 100 percent / hydrogen / Pd(OH)2/C / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; dmap; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jo050896w

Reference yield:

: 19462-24-9
N-phenylacetyltryptamine

: 712273-36-4
tert-butyl phenylacetyl-[2-(2-phenylsulfanyl-1H-indol-3-yl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / hydrochloric acid / dioxane / 0.08 h

2: 69 percent / NaH; 4-(dimethylamino)pyridine / tetrahydrofuran / 5 h

3: 90 percent / lithium hexamethyldisilazide; 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / 20 °C

4: 100 percent / hydrogen / Pd(OH)2/C / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; dmap; hydrogen; sodium hydride; lithium hexamethyldisilazane; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jo050896w