3-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-2-(4-methoxyphenyl)-1H-imidazo[1,2-a]pyridine

Base Information

Chemical Name:3-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-2-(4-methoxyphenyl)-1H-imidazo[1,2-a]pyridine
CAS No.:1417910-46-3
Molecular Formula:C₂₃H₁₈FN₅O
Molecular Weight:399.427
Hs Code.:

Synonyms:3-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-2-(4-methoxyphenyl)-1H-imidazo[1,2-a]pyridine

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Chemical Property of 3-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-2-(4-methoxyphenyl)-1H-imidazo[1,2-a]pyridine

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Technology Process of 3-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-2-(4-methoxyphenyl)-1H-imidazo[1,2-a]pyridine

There total 7 articles about 3-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-2-(4-methoxyphenyl)-1H-imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 766-98-3
1-ethynyl-4-fluorobenzene

: 1417910-26-9
C₁₅H₁₃N₅O

: 1417910-46-3
3-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-2-(4-methoxyphenyl)-1H-imidazo[1,2-a]pyridine

Guidance literature:: With copper(l) iodide; In water; at 20 ℃; for 4h;
DOI:10.1055/s-0032-1317379

Reference yield:

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 1417910-46-3
3-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-2-(4-methoxyphenyl)-1H-imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate / ethanol / 5 h / Reflux

2: trichlorophosphate / 1.5 h / 0 - 80 °C

3: sodium tetrahydroborate; methanol / 1 h / 20 °C

4: triethylamine / dichloromethane / 1 h / 0 - 20 °C

5: sodium azide / N,N-dimethyl-formamide / 14 h / 20 °C

6: copper(l) iodide / water / 4 h / 20 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; sodium azide; sodium hydrogencarbonate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1055/s-0032-1317379

Reference yield:

: 31562-99-9
2-(4-methoxyphenyl)imidazo[1,2-a]pyridine

: 1417910-46-3
3-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)-2-(4-methoxyphenyl)-1H-imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 1.5 h / 0 - 80 °C

2: sodium tetrahydroborate; methanol / 1 h / 20 °C

3: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4: sodium azide / N,N-dimethyl-formamide / 14 h / 20 °C

5: copper(l) iodide / water / 4 h / 20 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; sodium azide; triethylamine; trichlorophosphate; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1055/s-0032-1317379