1,3-bis(2-naphthylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine 2-oxide

Base Information

Chemical Name:1,3-bis(2-naphthylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine 2-oxide
CAS No.:180600-10-6
Molecular Formula:C₄₉H₄₇N₂O₄P
Molecular Weight:758.897
Hs Code.:

Synonyms:1,3-bis(2-naphthylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine 2-oxide

Suppliers and Price of 1,3-bis(2-naphthylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine 2-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,3-bis(2-naphthylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine 2-oxide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,3-bis(2-naphthylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine 2-oxide

There total 4 articles about 1,3-bis(2-naphthylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 939-26-4
2-bromomethylnaphthyl bromide

: 180600-08-2
(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bisoxy-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine-2-oxide

: 180600-10-6
1,3-bis(2-naphthylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine 2-oxide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 72h; Ambient temperature;
DOI:10.3987/com-96-7524

Reference yield:

: 153223-10-0
(2R,3S,4S,5R)-2,5-bis[N-(benzyloxycarbonyl)amino]-1,6-diphenyl-3,4-hexanediol

: 180600-10-6
1,3-bis(2-naphthylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine 2-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / camphor sulfonic acid / CH₂Cl₂ / 48 h / Ambient temperature

2: 100 percent / hydrogen / 10percent Pd/C / tetrahydrofuran; ethanol / 18 h / 760 Torr

3: 64 percent / triethylamine / tetrahydrofuran / 16 h / Ambient temperature

4: 50 percent / sodium hydride / dimethylformamide / 72 h / Ambient temperature

With camphor-10-sulfonic acid; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/com-96-7524

Reference yield:

: 177574-46-8
dibenzyl ((1R,1'R)-((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(2-phenylethane-1,1-diyl))dicarbamate

: 180600-10-6
1,3-bis(2-naphthylmethyl)-(4α,5α,6β,7β)-hexahydro-5,6-(1-methylethylidene)bis(oxy)-2-phenoxy-4,7-bisbenzyl-1H-1,3,2-diazaphosphepine 2-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / hydrogen / 10percent Pd/C / tetrahydrofuran; ethanol / 18 h / 760 Torr

2: 64 percent / triethylamine / tetrahydrofuran / 16 h / Ambient temperature

3: 50 percent / sodium hydride / dimethylformamide / 72 h / Ambient temperature

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.3987/com-96-7524