2-(furan-2-yl)-1H-imidazole

Base Information

• Chemical Name: 2-(furan-2-yl)-1H-imidazole
• CAS No.: 89795-49-3
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.137
• DSSTox Substance ID: DTXSID50349835
• Nikkaji Number: J855.322J
• Wikidata: Q72479711
• ChEMBL ID: CHEMBL1418698
• Mol file: 89795-49-3.mol

Synonyms:2-(furan-2-yl)-1H-imidazole;89795-49-3;2-FURAN-2-YL-1H-IMIDAZOLE;2-(2-FURANYL)-1H-IMIDAZOLE;furylimidazole;2-(2-furyl)-1H-imidazole;SMR000046485;MLS000082783;SCHEMBL5674960;CHEMBL1418698;DTXSID50349835;HMS2276A03;STL356496;AKOS011995109;SB61285;FT-0732979;Z995097334

Chemical Property of 2-(furan-2-yl)-1H-imidazole

Chemical Property:

• Vapor Pressure: 0.000364mmHg at 25°C
• Melting Point: 169-170 ºC
• Refractive Index: 1.567
• Boiling Point: 328.3°C at 760 mmHg
• Flash Point: 169.6°C
• PSA: 41.82000
• Density: 1.229
• LogP: 1.66970
• Storage Temp.: 2-8°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 134.048012819
• Heavy Atom Count: 10
• Complexity: 118

Purity/Quality:

98%min ^*data from raw suppliers

2-(Furan-2-yl)-1H-imidazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC(=C1)C2=NC=CN2

Technology Process of 2-(furan-2-yl)-1H-imidazole

There total 2 articles about 2-(furan-2-yl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-(2-furyl)-4,5-dihydro-1H-imidazole (40029-93-4) → 2-(2-furyl)imidazole (89795-49-3)

Guidance literature:

With 2% active carbon-supported palladium; In diphenylether; for 2h; Reflux;

DOI:10.1134/S1070427210060182

Reference yield:

furfural (98-01-1) + Glycolaldehyde (141-46-8) → 2-(2-furyl)imidazole (89795-49-3)

Guidance literature:

With ammonium hydroxide; copper (I) acetate; In methanol;

Reference yield:

2-(2-furyl)imidazole (89795-49-3) → 1-methyl-2-(5-benzoyl-2-furyl)imidazole (127702-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / 1,2-dimethoxy-ethane / 0.5 h / 8 °C

2: 54 percent / PPA / 140 °C

With potassium hydroxide; In 1,2-dimethoxyethane;

DOI:10.1007/BF00470698

upstream raw materials:

furfural

Glycolaldehyde

2-(2-furyl)-4,5-dihydro-1H-imidazole

Downstream raw materials:

1-methyl-2-(5-bromo-2-furyl)imidazole

1-methyl-2-(5-formyl-2-furyl)imidazole

1-methyl-2-(5-benzoyl-2-furyl)imidazole