3-(2-(4-methoxyphenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-imidazol-3-ium bromide

Base Information

Chemical Name:3-(2-(4-methoxyphenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-imidazol-3-ium bromide
CAS No.:1447799-66-7
Molecular Formula:Br*C₂₇H₂₃N₂O₃
Molecular Weight:503.395
Hs Code.:

Synonyms:3-(2-(4-methoxyphenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-imidazol-3-ium bromide

Suppliers and Price of 3-(2-(4-methoxyphenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-imidazol-3-ium bromide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-(4-methoxyphenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-imidazol-3-ium bromide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(2-(4-methoxyphenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-imidazol-3-ium bromide

There total 8 articles about 3-(2-(4-methoxyphenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-imidazol-3-ium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1447799-58-7
1-((2-phenylbenzofuran-3-yl)methyl)-1H-imidazole

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 1447799-66-7
3-(2-(4-methoxyphenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-imidazol-3-ium bromide

Guidance literature:: In toluene; Reflux;
DOI:10.1016/j.bmcl.2013.06.001

Reference yield:

: 90-02-8
salicylaldehyde

: 1447799-66-7
3-(2-(4-methoxyphenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-imidazol-3-ium bromide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C

2: potassium tert-butylate / N,N-dimethyl-formamide / 6 h / Inert atmosphere; Reflux

3: trichlorophosphate / 30 h / 100 °C

4: sodium tetrahydroborate / methanol / 4.33 h / 0 - 20 °C

5: triethylamine / dichloromethane / 2 h / 0 - 20 °C

6: toluene / Reflux

7: toluene / Reflux

With sodium tetrahydroborate; potassium tert-butylate; potassium carbonate; triethylamine; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.bmcl.2013.06.001

Reference yield:

: 100-39-0
benzyl bromide

: 1447799-66-7
3-(2-(4-methoxyphenyl)-2-oxoethyl)-1-((2-phenylbenzofuran-3-yl)methyl)-1H-imidazol-3-ium bromide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 100 °C

2: potassium tert-butylate / N,N-dimethyl-formamide / 6 h / Inert atmosphere; Reflux

3: trichlorophosphate / 30 h / 100 °C

4: sodium tetrahydroborate / methanol / 4.33 h / 0 - 20 °C

5: triethylamine / dichloromethane / 2 h / 0 - 20 °C

6: toluene / Reflux

7: toluene / Reflux

With sodium tetrahydroborate; potassium tert-butylate; potassium carbonate; triethylamine; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.bmcl.2013.06.001