{4,5-Dimethoxy-10-[1-trimethylsilanyl-meth-(E)-ylidene]-13-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-13-yl}-phenyl-methanone

Base Information

• Chemical Name: {4,5-Dimethoxy-10-[1-trimethylsilanyl-meth-(E)-ylidene]-13-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-13-yl}-phenyl-methanone
• CAS No.: 263570-39-4
• Molecular Formula: C₂₅H₃₁NO₃Si
• Molecular Weight: 421.612

Synonyms:{4,5-Dimethoxy-10-[1-trimethylsilanyl-meth-(E)-ylidene]-13-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-13-yl}-phenyl-methanone

Chemical Property of {4,5-Dimethoxy-10-[1-trimethylsilanyl-meth-(E)-ylidene]-13-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-13-yl}-phenyl-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {4,5-Dimethoxy-10-[1-trimethylsilanyl-meth-(E)-ylidene]-13-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-13-yl}-phenyl-methanone

There total 10 articles about {4,5-Dimethoxy-10-[1-trimethylsilanyl-meth-(E)-ylidene]-13-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-13-yl}-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-(o-iodobenzoyl)-6,7-dimethoxy-1-[4-(trimethylsilyl)but-3-ynyl]-1,2,3,4-tetrahydroisoquinoline (263570-37-2) → {4,5-Dimethoxy-10-[1-trimethylsilanyl-meth-(E)-ylidene]-13-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-13-yl}-phenyl-methanone (263570-39-4)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 2h; Heating;

DOI:10.3987/COM-99-S91

Reference yield:

2-Iodobenzoyl chloride (609-67-6) → {4,5-Dimethoxy-10-[1-trimethylsilanyl-meth-(E)-ylidene]-13-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-13-yl}-phenyl-methanone (263570-39-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N; DMAP / benzene / 24 h / 20 °C

2: 65 percent / Bu₃SnH; AIBN / toluene / 2 h / Heating

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; In toluene; benzene; 1: Acylation / 2: Reduction;

DOI:10.3987/COM-99-S91

Reference yield:

1-(but-3-en-1-yl)-6,7-dimethoxy-3,4-dihydroisoquinoline (740026-99-7) → {4,5-Dimethoxy-10-[1-trimethylsilanyl-meth-(E)-ylidene]-13-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-13-yl}-phenyl-methanone (263570-39-4)

Guidance literature:

Multi-step reaction with 8 steps

1.1: NaBH₄

2.1: Et₃N; DMAP / ethyl acetate / 24 h / 20 °C

3.1: 4 percent aq. OsO₄ / tetrahydrofuran / 0.25 h / 0 °C

3.2: NaIO₄ / tetrahydrofuran; H₂O / 24 h / 20 °C

4.1: 73 percent / PPh₃; t-BuOK / toluene / 1 h / -20 °C

5.1: n-BuLi; TMEDA / tetrahydrofuran / 1 h / -78 °C

5.2: 61 percent / tetrahydrofuran / 24 h / 20 °C

6.1: TMS-I / acetonitrile / 0.25 h / 20 °C

7.1: Et₃N; DMAP / benzene / 24 h / 20 °C

8.1: 65 percent / Bu₃SnH; AIBN / toluene / 2 h / Heating

With dmap; sodium tetrahydroborate; osmium(VIII) oxide; n-butyllithium; 2,2'-azobis(isobutyronitrile); trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; potassium tert-butylate; tri-n-butyl-tin hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; ethyl acetate; toluene; acetonitrile; benzene; 1.1: Reduction / 2.1: Acylation / 3.1: Oxidation / 3.2: Oxidation / 4.1: Condensation / 5.1: Elimination / 5.2: Substitution / 6.1: Substitution / 7.1: Acylation / 8.1: Reduction;

DOI:10.3987/COM-99-S91

upstream raw materials:

2-(o-iodobenzoyl)-6,7-dimethoxy-1-[4-(trimethylsilyl)but-3-ynyl]-1,2,3,4-tetrahydroisoquinoline

2-Iodobenzoyl chloride

1-(but-3-en-1-yl)-6,7-dimethoxy-3,4-dihydroisoquinoline

1-(but-3-enyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Downstream raw materials:

(4,5-dimethoxy-10-methylene-13-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-13-yl)-phenyl-methanone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 263570-39-4 {4,5-Dimethoxy-10-[1-trimethylsilanyl-meth-(E)-ylidene]-13-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-13-yl}-phenyl-methanone

Send

Send

Metric Ton KG G Pound L ML

Send

Send