5-Bromo-4,6-dimethyl-3-nitropyridin-2-amine

Base Information

• Chemical Name: 5-Bromo-4,6-dimethyl-3-nitropyridin-2-amine
• CAS No.: 89791-76-4
• Molecular Formula: C7H8 Br N3 O2
• Molecular Weight: 246.06
• Hs Code.: 2933399090
• European Community (EC) Number: 620-940-0
• UNII: 6U7DJ595BX
• DSSTox Substance ID: DTXSID20394655
• Wikidata: Q82194179
• Mol file: 89791-76-4.mol

Synonyms:89791-76-4;5-bromo-4,6-dimethyl-3-nitropyridin-2-amine;2-Amino-5-bromo-4,6-dimethyl-3-nitropyridine;2-Amino-3-nitro-4,6-dimethyl-5-bromopyridine;6U7DJ595BX;2-Pyridinamine, 5-bromo-4,6-dimethyl-3-nitro-;UNII-6U7DJ595BX;SCHEMBL1625081;DTXSID20394655;AWUOLSBKAQIADQ-UHFFFAOYSA-N;AC7164;MFCD03931432;AKOS022178401;2-amino-5-bromo-3-nitro-4,6-lutidine;SY028388;CS-0325970;FT-0762288;5-bromo-4,6-dimethyl-3-nitro-2-pyridinylamine

Chemical Property of 5-Bromo-4,6-dimethyl-3-nitropyridin-2-amine

Chemical Property:

• PSA: 84.73000
• LogP: 3.05570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 244.97999
• Heavy Atom Count: 13
• Complexity: 208

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-5-bromo-4,6-dimethyl-3-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=NC(=C1Br)C)N)[N+](=O)[O-]

Technology Process of 5-Bromo-4,6-dimethyl-3-nitropyridin-2-amine

There total 3 articles about 5-Bromo-4,6-dimethyl-3-nitropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-amino-5-bromo-4,6-dimethylpyridine (89856-44-0) → 2-amino-3-nitro-4,6-dimethyl-5-bromo-pyridine (89791-76-4)

Guidance literature:

With sulfuric acid; nitric acid; at -10 - 20 ℃; for 0.5h;

DOI:10.1016/S0968-0896(97)00012-6

Reference yield:

2-Amino-4,6-dimethylpyridine (5407-87-4) → 2-amino-3-nitro-4,6-dimethyl-5-bromo-pyridine (89791-76-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / bromine; glacial acetic acid / 1.33 h / 20 °C

2: 64 percent / potassium nitrate; concd. sulfuric acid / 1 h / 20 °C

With sulfuric acid; bromine; acetic acid; potassium nitrate;

DOI:10.1002/jhet.5570400403

Reference yield:

→ 2-amino-3-nitro-4,6-dimethyl-5-bromo-pyridine (89791-76-4)

Guidance literature:

2-Nitramino-5-brom-4,6-dimethyl-pyridin, konz. H2SO4, Δ;

upstream raw materials:

2-amino-5-bromo-4,6-dimethylpyridine

2-Amino-4,6-dimethylpyridine

Downstream raw materials:

5,7-dimethyl-1H-[1,2,3]triazolo[4,5-b]pyridine

6-bromo-5,7-dimethyl-1H-[1,2,3]triazolo[4,5-b]pyridine

5,7-dimethyl-1(3)H-imidazo[4,5-b]pyridine

6-bromo-5,7-dimethyl-1⁽³⁾H-imidazo[4,5-b]pyridine