N-[4-(4-hydroxyphenyl)butyryl]-L-prolyl-DL-α-methylphenylalanyl-L-arginine

Base Information

Chemical Name:N-[4-(4-hydroxyphenyl)butyryl]-L-prolyl-DL-α-methylphenylalanyl-L-arginine
CAS No.:86787-35-1
Molecular Formula:C₃₁H₄₂N₆O₆
Molecular Weight:594.711
Hs Code.:

Synonyms:N-[4-(4-hydroxyphenyl)butyryl]-L-prolyl-DL-α-methylphenylalanyl-L-arginine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-(4-hydroxyphenyl)butyryl]-L-prolyl-DL-α-methylphenylalanyl-L-arginine

Chemical Property:

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Technology Process of N-[4-(4-hydroxyphenyl)butyryl]-L-prolyl-DL-α-methylphenylalanyl-L-arginine

There total 9 articles about N-[4-(4-hydroxyphenyl)butyryl]-L-prolyl-DL-α-methylphenylalanyl-L-arginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 88105-93-5
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methylphenylalanyl-N^ω-nitro-L-arginine

: 86787-35-1
N-[4-(4-hydroxyphenyl)butyryl]-L-prolyl-DL-α-methylphenylalanyl-L-arginine

Guidance literature:: With hydrogen; acetic acid; Pd-BaSO₄; In ethanol; for 18h; under 3102.9 Torr;
DOI:10.1021/jm00369a017

Reference yield:

: 7021-11-6
4-(4-hydroxyphenyl)butanoic acid

: 86787-35-1
N-[4-(4-hydroxyphenyl)butyryl]-L-prolyl-DL-α-methylphenylalanyl-L-arginine

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 17 h / 25 °C / pH 7.0-7.5

2: 100 percent / H₂ / 10percent Pd/C (wet with H₂O) / ethanol / 3 h / 3102.9 Torr

3: 96 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

4: 81 percent / 2.5 N NaOH / methanol / 25 °C

5: 95 percent / HOBt, NEM, DCC / tetrahydrofuran / 48 h / pH 7.0-7.5

6: 75 percent / 2.5 N NaOH / methanol / 25 °C

7: 88 percent / H₂, AcOH / 10percent Pd/BaSO₄ (wet with H₂O) / ethanol / 18 h / 3102.9 Torr

With N-Ethylmaleimide; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on carbon; Pd-BaSO₄; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00369a017

Reference yield:

: 22320-10-1
methyl 4-(4-hydroxyphenyl)butanoate

: 86787-35-1
N-[4-(4-hydroxyphenyl)butyryl]-L-prolyl-DL-α-methylphenylalanyl-L-arginine

Guidance literature:: Multi-step reaction with 8 steps

1: 48percent HBr / acetic acid / Heating

2: 83 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 17 h / 25 °C / pH 7.0-7.5

3: 100 percent / H₂ / 10percent Pd/C (wet with H₂O) / ethanol / 3 h / 3102.9 Torr

4: 96 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

5: 81 percent / 2.5 N NaOH / methanol / 25 °C

6: 95 percent / HOBt, NEM, DCC / tetrahydrofuran / 48 h / pH 7.0-7.5

7: 75 percent / 2.5 N NaOH / methanol / 25 °C

8: 88 percent / H₂, AcOH / 10percent Pd/BaSO₄ (wet with H₂O) / ethanol / 18 h / 3102.9 Torr

With N-Ethylmaleimide; sodium hydroxide; hydrogen bromide; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on carbon; Pd-BaSO₄; In tetrahydrofuran; methanol; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00369a017