C₃₅H₅₂O₂Si

Base Information

• Chemical Name: C₃₅H₅₂O₂Si
• CAS No.: 1334336-44-5
• Molecular Formula: C₃₅H₅₂O₂Si
• Molecular Weight: 532.882
• Mol file: 1334336-44-5.mol

Synonyms:C₃₅H₅₂O₂Si

Chemical Property of C₃₅H₅₂O₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₅H₅₂O₂Si

There total 5 articles about C₃₅H₅₂O₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

3-tert-butylbenzyl bromide (102405-32-3) + 3-(O-tert-butyl(dimethyl)silyl)estrone (57711-40-7) → C35H52O2Si (1334336-44-5)

Guidance literature:

3-tert-butylbenzyl bromide; With magnesium; In diethyl ether; at 20 ℃; for 2h; Inert atmosphere;

3-(O-tert-butyl(dimethyl)silyl)estrone; In tetrahydrofuran; diethyl ether; at 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

DOI:10.1016/j.ejmech.2011.06.027

Reference yield:

3-tert-butylphenyol (585-34-2) → C35H52O2Si (1334336-44-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C

2.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 20 - 90 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C

5.1: magnesium / diethyl ether / 2 h / 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; carbon tetrabromide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; magnesium; triethylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 5.1: Grignard reaction / 5.2: Grignard reaction;

DOI:10.1016/j.ejmech.2011.06.027

Reference yield:

m-(tert-butyl)phenyl trifluoromethanesulfonate (201851-06-1) → C35H52O2Si (1334336-44-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 20 - 90 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C

4.1: magnesium / diethyl ether / 2 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; carbon tetrabromide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; magnesium; triethylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 4.1: Grignard reaction / 4.2: Grignard reaction;

DOI:10.1016/j.ejmech.2011.06.027

upstream raw materials:

3-tert-butylphenyol

3-tert-butylbenzyl alcohol

methyl 3-(tert-butyl)benzoate

3-tert-butylbenzyl bromide

Downstream raw materials:

(17β)-17-(3-tert-butylbenzyl)-estra-1(10),2,4-triene-3,17-diol