102405-32-3

Basic information

• Product Name: Benzene, 1-(bromomethyl)-3-(1,1-dimethylethyl)-
• CAS NO: 102405-32-3
• Molecular Formula: C11H15Br
• Molecular Weight: 227.144
• Mol File: 102405-32-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(bromomethyl)-3-(1,1-dimethylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(bromomethyl)-3-(1,1-dimethylethyl)-(102405-32-3)
• EPA Substance Registry System: Benzene, 1-(bromomethyl)-3-(1,1-dimethylethyl)-(102405-32-3)

Safety Data

• Hazardous Substances Data: 102405-32-3(Hazardous Substances Data)

Upstream product

• 201851-06-1 m-(tert-butyl)phenyl trifluoromethanesulfonate 
• 27330-57-0 methyl 3-(tert-butyl)benzoate 
• 51503-09-4 3-tert-butylbenzyl alcohol 
• 585-34-2 3-tert-butylphenyol 
• 103668-90-2 2-oxatricyclo<2.2.2.0^3,5>octan-6-one 
• 1075-38-3 m-t-butyltoluene 
• 103668-93-5 6-tert-butyl-2-oxatricyclo<2.2.2.0^3,5>octan-6-ol 

Downstream Products

• 7498-54-6 3-t-Butylbenzoic acid 
• 1215115-65-3 (17β)-17-(3-tert-butylbenzyl)-estra-1(10),2,4-triene-3,17-diol 
• 1334336-44-5 C₃₅H₅₂O₂Si 
• 1166974-45-3 C₁₅H₁₈N₂O 
• 121801-98-7 1-[Benzo[b]thiophen-3-yl-(3-tert-butyl-phenyl)-methyl]-1H-imidazole 
• 121801-71-6 Benzo[b]thiophen-3-yl-(3-tert-butyl-phenyl)-methanol 
• 121801-84-1 3-[(3-tert-Butyl-phenyl)-chloro-methyl]-benzo[b]thiophene 
• 23039-28-3 3-(tert-butyl)benzaldehyde 
• 51503-09-4 3-tert-butylbenzyl alcohol 

Relevant articles and documents

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Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase

Steroid sulfatase (STS) controls the levels of 3-hydroxysteroids available from circulating steroid sulfates in several normal and malignant tissues. This and the known involvement of active estrogens and androgens in diseases such as breast and prostate cancers thus make STS an interesting therapeutic target. Here we describe the chemical synthesis and characterization of an extended series of 17α-derivatives of estradiol (E2) using different strategies. A variant of the samarium-Barbier reaction with stoichiometric samarium metal and catalytic Kagan reagent formation was used for introducing low reactive benzyl substrates in position 17 of estrone (E1) whereas heterocyclic substrates were metalated and reacted with either the carbonyl or the 17-oxirane of E1. In vitro evaluation of the inhibitory potency of the new compounds against STS identified new inhibitors and allowed a more complete structure-activity relationship study of this family of 17α-derivatives of E2.

New enzymes and prodrugs for ADEPT

The present invention relates to nucleic acid molecules encoding mutant human carboxypeptidase A enzymes, and encoding conjugates of targeting molecules and mutant human carboxypeptidase A enzymes. The invention further relates to vectors and cell lines containing such nucleic acid molecules.