2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N-methyl-5-(1-methylethyl)-1-benzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N-methyl-5-(1-methylethyl)-1-benzofuran-3-carboxamide
CAS No.:1378427-29-2
Molecular Formula:C₂₄H₂₈BFN₂O₆S
Molecular Weight:502.372
Hs Code.:

Synonyms:2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N-methyl-5-(1-methylethyl)-1-benzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N-methyl-5-(1-methylethyl)-1-benzofuran-3-carboxamide

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Technology Process of 2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N-methyl-5-(1-methylethyl)-1-benzofuran-3-carboxamide

There total 8 articles about 2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N-methyl-5-(1-methylethyl)-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400072-72-1
C₃₇H₄₆BFN₂O₇S

: 1378427-29-2
2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N-methyl-5-(1-methylethyl)-1-benzofuran-3-carboxamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 48h; under 3000.3 Torr;

Reference yield:

: 691857-51-9
ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

: 1378427-29-2
2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N-methyl-5-(1-methylethyl)-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 25 h / Inert atmosphere; Reflux

2: hydrogen / palladium on activated charcoal / ethyl acetate / 12 h / 20 °C / 760.05 Torr

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

4: potassium hydroxide; water / ethanol / 0.5 h / Reflux

5: triethylamine; HATU / N,N-dimethyl-formamide / 15 h / Inert atmosphere

6: potassium carbonate / acetonitrile / Reflux

7: bis(1,5-cyclooctadiene)diiridium(I) dichloride / tetrahydrofuran / 48 h / 0 - 20 °C / Inert atmosphere

8: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 3000.3 Torr

With potassium fluoride; water; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium bromide; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(1,5-cyclooctadiene)diiridium(I) dichloride; palladium 10% on activated carbon; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1378428-80-8
2-(4-fluorophenyl)-5-(1-methylethyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid

: 1378427-29-2
2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborolan-4-yl)methyl](methylsulfonyl)amino]-N-methyl-5-(1-methylethyl)-1-benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; HATU / N,N-dimethyl-formamide / 15 h / Inert atmosphere

2: potassium carbonate / acetonitrile / Reflux

3: bis(1,5-cyclooctadiene)diiridium(I) dichloride / tetrahydrofuran / 48 h / 0 - 20 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 3000.3 Torr

With hydrogen; potassium carbonate; triethylamine; HATU; bis(1,5-cyclooctadiene)diiridium(I) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;