ethyl 6-amino-2-(4-fluorophenyl)-5-(1-methylethyl)-1-benzofuran-3-carboxylate

Base Information

Chemical Name:ethyl 6-amino-2-(4-fluorophenyl)-5-(1-methylethyl)-1-benzofuran-3-carboxylate
CAS No.:1378428-79-5
Molecular Formula:C₂₀H₂₀FNO₃
Molecular Weight:341.382
Hs Code.:

Synonyms:ethyl 6-amino-2-(4-fluorophenyl)-5-(1-methylethyl)-1-benzofuran-3-carboxylate

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Chemical Property of ethyl 6-amino-2-(4-fluorophenyl)-5-(1-methylethyl)-1-benzofuran-3-carboxylate

Chemical Property:

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Technology Process of ethyl 6-amino-2-(4-fluorophenyl)-5-(1-methylethyl)-1-benzofuran-3-carboxylate

There total 2 articles about ethyl 6-amino-2-(4-fluorophenyl)-5-(1-methylethyl)-1-benzofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: ethyl 2-(4-fluorophenyl)-5-(1-methylethenyl)-6-nitro-1-benzofuran-3-carboxylate

: 1378428-79-5
ethyl 6-amino-2-(4-fluorophenyl)-5-(1-methylethyl)-1-benzofuran-3-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 12h; under 760.051 Torr;

Reference yield:

: 691857-51-9
ethyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

: 1378428-79-5
ethyl 6-amino-2-(4-fluorophenyl)-5-(1-methylethyl)-1-benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 25 h / Inert atmosphere; Reflux

2: hydrogen / palladium on activated charcoal / ethyl acetate / 12 h / 20 °C / 760.05 Torr

With potassium fluoride; hydrogen; sodium bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In water; ethyl acetate; toluene;

Reference yield:

: 1378428-79-5
ethyl 6-amino-2-(4-fluorophenyl)-5-(1-methylethyl)-1-benzofuran-3-carboxylate

: 1400072-72-1
C₃₇H₄₆BFN₂O₇S

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

2: potassium hydroxide; water / ethanol / 0.5 h / Reflux

3: triethylamine; HATU / N,N-dimethyl-formamide / 15 h / Inert atmosphere

4: potassium carbonate / acetonitrile / Reflux

5: bis(1,5-cyclooctadiene)diiridium(I) dichloride / tetrahydrofuran / 48 h / 0 - 20 °C / Inert atmosphere

With water; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; bis(1,5-cyclooctadiene)diiridium(I) dichloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;