C₁₃H₁₈F₂N₂O₂

Base Information

Chemical Name:C₁₃H₁₈F₂N₂O₂
CAS No.:1353530-98-9
Molecular Formula:C₁₃H₁₈F₂N₂O₂
Molecular Weight:272.295
Hs Code.:

C<sub>13</sub>H<sub>18</sub>F<sub>2</sub>N<sub>2</sub>O<sub>2</sub>

Synonyms:C₁₃H₁₈F₂N₂O₂

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₃H₁₈F₂N₂O₂

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Technology Process of C₁₃H₁₈F₂N₂O₂

There total 5 articles about C₁₃H₁₈F₂N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.1%

: 1353530-97-8
C₂₁H₂₄F₂N₂O₄

: 1353530-98-9
C₁₃H₁₈F₂N₂O₂

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 2h;

Reference yield:

: 1353530-95-6
C₁₈H₁₇BrF₂N₂O₂

: 1353530-98-9
C₁₃H₁₈F₂N₂O₂

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium fluoride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 6 h / Inert atmosphere; Reflux

2.1: methanesulfonamide; AD-mix α / tert-butyl alcohol / 20 °C

2.2: 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C

With methanesulfonamide; AD-mix α; hydrogen; cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; ethyl acetate; tert-butyl alcohol;

Reference yield:

: 399-94-0
2-bromo-1,4-difluorobenzene

: 1353530-98-9
C₁₃H₁₈F₂N₂O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium t-butanolate; ruphos / bis(dibenzylideneacetone)-palladium⁽⁰⁾ / toluene / 1 h / 100 °C / Inert atmosphere

2.1: N-Bromosuccinimide / dichloromethane / 1.5 h / 20 °C

3.1: cesium fluoride / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 6 h / Inert atmosphere; Reflux

4.1: methanesulfonamide; AD-mix α / tert-butyl alcohol / 20 °C

4.2: 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C

With N-Bromosuccinimide; methanesulfonamide; AD-mix α; hydrogen; cesium fluoride; sodium t-butanolate; ruphos; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; ethyl acetate; toluene; tert-butyl alcohol;