N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-2,3-difluorobenzoyl)piperazin-1-yl)methyl)benzamide hydrochloride

Base Information

Chemical Name:N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-2,3-difluorobenzoyl)piperazin-1-yl)methyl)benzamide hydrochloride
CAS No.:1124448-01-6
Molecular Formula:C₂₈H₃₅F₂N₅O₃
Molecular Weight:527.614
Hs Code.:

Synonyms:N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-2,3-difluorobenzoyl)piperazin-1-yl)methyl)benzamide hydrochloride

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Chemical Property of N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-2,3-difluorobenzoyl)piperazin-1-yl)methyl)benzamide hydrochloride

Chemical Property:

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Technology Process of N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-2,3-difluorobenzoyl)piperazin-1-yl)methyl)benzamide hydrochloride

There total 5 articles about N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-2,3-difluorobenzoyl)piperazin-1-yl)methyl)benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 1124214-10-3
3-((4-(4-amino-2,3-difluorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

: 2516-34-9
cyclobutylamine

: 1124448-01-6
N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-2,3-difluorobenzoyl)piperazin-1-yl)methyl)benzamide hydrochloride

Guidance literature:: bis(trichloromethyl) carbonate; 3-((4-(4-amino-2,3-difluorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.533333h;

cyclobutylamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h;

Reference yield:

: 1094362-66-9
N-tert-butyl-3-(chloromethyl)benzamide

: 1124448-01-6
N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-2,3-difluorobenzoyl)piperazin-1-yl)methyl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / 60 °C

3.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dichloromethane; ethyl acetate

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.53 h

4.2: 2 h

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1124212-41-4
N-tert-butyl-3-(piperazin-1-ylmethyl)benzamide

: 1124448-01-6
N-tert-butyl-3-((4-(4-(3-cyclobutylureido)-2,3-difluorobenzoyl)piperazin-1-yl)methyl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dichloromethane; ethyl acetate

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.53 h

2.2: 2 h

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate;