4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1392429-50-3
Molecular Formula:C₃₁H₃₇F₂N₇O₄S
Molecular Weight:641.742
Hs Code.:

4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Synonyms:4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

There total 11 articles about 4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1392429-98-9
4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-iodo-1H-pyrrolo[3,2- b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

: 109299-78-7
pyrimidine 5-boronic acid

: 1392429-50-3
4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; lithium chloride; In 1,4-dioxane; water; at 100 ℃; for 1h;
DOI:10.1021/acs.jmedchem.9b02083

Reference yield:

: 1392429-92-3
N-(2,4-difluoro-3-iodophenyl) propane-1-sulfonamide

: 1392429-50-3
4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / toluene / 40 h / 120 °C / Inert atmosphere

2: N-iodo-succinimide / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

3: sodium carbonate; lithium chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

With N-iodo-succinimide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium carbonate; caesium carbonate; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; 1: Ullmann Reaction / 3: Suzuki Coupling;

Reference yield:

: 1392429-88-7
tert-butyl 4-(methyl-(1H-pyrrolo[3,2-b]pyridin-5-yl)amino)piperidine-1-carboxylate

: 1392429-50-3
4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / toluene / 40 h / 120 °C / Inert atmosphere

2: N-iodo-succinimide / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

3: sodium carbonate; lithium chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

With N-iodo-succinimide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium carbonate; caesium carbonate; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; 1: Ullmann Reaction / 3: Suzuki Coupling;